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== Summary == ==== Title: (or description) ==== Key [[Neurology of ME/CFS|neurological pathomechanisms]] in [[ME/CFS]] are [[intracranial hypertension]], impaired cerebral blood flow, Hyperventilation/hypocapnia, and adrenergic hyperactivity. Decreased CBF, disturbed local blood flow regulation and neurovascular coupling, central adrenergic hyperactivity, hypocapnia and increase in intracranial presssure seem to play a strong role in the pathophysiology of the neurological symptoms in ME/CFS (Fig.Β 1). They can well explain cognitive impairment, brain fog, headache, psychomotor slowing, ataxia and loss of coordination of movements, hypersensitivity, sleep disturbances and dysautonomia. ==== Author: (or citation) ==== Wirth, K.J., Scheibenbogen, C. & Paul, F. [https://doi.org/10.1186/s12967-021-03143-3 An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.] An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. J Transl Med 19, 471 (2021). https://doi.org/10.1186/s12967-021-03143-3<ref name="Wirth2021b">{{Cite journal|last=Wirth | first = Klaus J. | author-link = | last2 = Scheibenbogen | first2 = Carmen | author-link2 = Carmen Scheibenbogen | last3 = Paul | first3 = Friedemann | author-link3 = | date = 2021-11-22 | title = An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|url=https://doi.org/10.1186/s12967-021-03143-3|journal=Journal of Translational Medicine|volume=19|issue=1|pages=471|doi=10.1186/s12967-021-03143-3|issn=1479-5876|pmc=PMC8607226|pmid=34809664|access-date=|quote=|via=}}</ref> ==== Source: (e.g. internet address) ==== [https://doi.org/10.1186/s12967-021-03143-3 An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.] https://doi.org/10.1186/s12967-021-03143-3 ==== Other information: ==== ==== See also ==== *[[Cognitive dysfunction]] *[[Neurology of ME/CFS]] *[[Neuroinflammation]] ====References ==== {{Reflist}} == Licensing == {{CC-by-4.0}} [[Category:ME and CFS awareness images]] [[Category:Images]] [[Category:Images for journalists]]
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