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BCG vaccination
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{{stub}} '''Bacille Calmette-Guérin vaccination''' or BCG vaccination is a vaccination which been used to protest against tuberculosis (TB) for over 100 years. More recently, BCG vaccines have been found to cause more wide-ranging and positive immune system effects<ref name="Takahashi2022"/> and has been suggested as a treatment for [[Fibromyalgia]]<ref name="Behm2022"/> and [[COVID-19]].{{citation needed| date = Mar 2023}} ==Theory== ==Evidence== ===Fibromyalgia clinical trial=== A planned trial of three BCG vaccine doses for people with fibromyalgia was approved by the FDA but was withdrawn in 2022.<ref name="NCT03582085">{{Cite web | title = Phase II Clinical Trial: Multi-dosing the BCG Vaccine for Fibromyalgia | date = 2022-04-05 | url = https://clinicaltrials.gov/ct2/show/NCT03582085 | website = Clinical Trials|last=Faustman | first = Denise Louise | author-link = Denise Faustman | last2 = Massachusetts General Hospital|access-date=2023-03-04|quote=|via=}}</ref> ==Clinicians== ==Risks and safety== ==Cost and availability== ==Notable studies == * 2022, BCG vaccinations drive epigenetic changes to the human T cell receptor: Restored expression in type 1 diabetes<ref name="Takahashi2022">https://doi.org/10.1126%2Fsciadv.abq7240</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9668301/ (Full text)] *2012, Unique immunologic patterns in fibromyalgia<ref name="Behm2022">http://www.biomedcentral.com/1472-6890/12/25</ref> - [http://www.biomedcentral.com/1472-6890/12/25 (Full text)] ==News and articles == * 2023, [https://www.scientificamerican.com/article/an-old-tb-vaccine-might-help-stave-off-diabetes-cancer-alzheimers-and-more/ An Old TB Vaccine Might Help Stave Off Diabetes, Cancer Alzheimer's, and More] - Scientific American * 2021, [https://www.statnews.com/2021/10/20/selling-certainty-epicgenetics-physician-was-one-of-fibromyalgia-patients-few-true-allies-or-was-he/ An Old TB Vaccine Might Help Stave Off] - STAT News *2020, [http://web.archive.org/web/20220927153406/https://blogs.cdc.gov/genomics/2020/08/10/beyond-tuberculosis/ Beyond Tuberculosis: BCG Vaccine and Epigenetics] - CDC blog (archived copy) * 2017, [http://web.archive.org/web/20200811013738/https://www.prohealth.com/library/century-old-vaccine-gives-new-hope-to-fibromyalgia-community-42689 Century-Old Vaccine Gives New Hope To Fibromyalgia Community] - ProHealth.com (archived copy) ==See also== *[[Fibromyalgia drugs]] *[[T cell]] *[[Fibromyalgia]] ==Learn more== * 2023, [https://www.scientificamerican.com/article/an-old-tb-vaccine-might-help-stave-off-diabetes-cancer-alzheimers-and-more/ An Old TB Vaccine Might Help Stave Off Diabetes, Cancer Alzheimer's, and More] - Scientific American * 2021, [https://www.statnews.com/2021/10/20/selling-certainty-epicgenetics-physician-was-one-of-fibromyalgia-patients-few-true-allies-or-was-he/ An Old TB Vaccine Might Help Stave Off] - STAT News ==References== {{reflist}} [[Category:Potential treatments]] [[Category:Alternative medicine]] [[Category:Immunomodulators]] [[Category:Immunostimulants]] [[Category:Vaccines]]
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