Vascular endothelial growth factor
Vascular Endothelial Growth Factor (VEGF) or Vascular Endothelial Growth Factor A (VEGF-A) is a signal protein produced by cells that stimulates blood vessel formation (vasculogenesis and angiogenesis). Vascular Endothelial Growth Factor was originally known as vascular permeability factor (VPF).
The VEGF family help maintain blood vessel and lymphatic systems.
ME/CFS[edit | edit source]
Landi et al. (2016) found lower levels of VEGF, IL-7 and IL-16 in 100 long-term ME/CFS patients compared to controls but studies by Horning et al. (2015) and Montoya et al. (2017) did not find this statistically significant.
Notable studies[edit | edit source]
- 2016, Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome
See also[edit | edit source]
Learn more[edit | edit source]
References[edit | edit source]
- Maniscalco, W. M.; D’Angio, C. T. (Jan 1, 2006). Laurent, Geoffrey J.; Shapiro, Steven D., eds. "VASCULAR ENDOTHELIAL GROWTH FACTOR". Oxford: Academic Press: 413–418. ISBN 978-0-12-370879-3.
- Landi, Abdolamir; Broadhurst, David; Vernon, Suzanne D.; Tyrrell, D. Lorne J.; Houghton, Michael (Feb 2016). "Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome". Cytokine. 78: 27–36. doi:10.1016/j.cyto.2015.11.018. ISSN 1096-0023. PMID 26615570.
- Giloteaux, Ludovic; O’Neal, Adam; Castro-Marrero, Jesús; Levine, Susan M.; Hanson, Maureen R. (Oct 12, 2020). "Cytokine profiling of extracellular vesicles isolated from plasma in myalgic encephalomyelitis/chronic fatigue syndrome: a pilot study". Journal of Translational Medicine. 18 (1): 387. doi:10.1186/s12967-020-02560-0. ISSN 1479-5876.
myalgic encephalomyelitis (ME) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.
chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.