Body temperature

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The normal human body temperature range is typically stated as 36.5–37.5 °C (97.7–99.5 °F). The average internal temperature is 37.0 °C (98.6 °F). It is typically maintained within this range by thermoregulation. Body temperature normally fluctuates over the day following circadian rhythms, with the lowest levels around 4 a.m. and the highest in the late afternoon.

Core temperature is regulated and stabilized primarily by the hypothalamus, a region of the brain linking the endocrine system to the nervous system.

Pathophysiology[edit | edit source]

In ME/CFS[edit | edit source]

Temperature sensitivity, or intolerance to the heat or cold, occurs commonly as a symptom in ME/CFS, and is recognised in the Canadian Consensus Criteria as a neuroendocrine symptom.

  • 53.9% - 58.7% of the 2073 patients in a Belgian study of 2001 reported symptom exacerbation in extremes of temperature.[1]
  • Katrina Berne reports a prevalence of 75-80% for heat/cold intolerance.[2]

Temperature intolerance is featured as a symptom in the International Consensus Criteria. In the London criteria, sensitivity to both heat and cold is mentioned under the criteria of periods of impaired circulation compatible with autonomic dysfunction.[3]

References[edit | edit source]

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.