Talk:Mast cell activation syndrome

This review article may be helpful for expanding this page: http://www.ncbi.nlm.nih.gov/pubmed/23179866 --JenB (talk) 14:17, 14 February 2016 (PST)

Also to add:

ME/CFS + mast cell activation https://www.medscape.com/viewarticle/893858

Gender: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4417946/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120457/

--JenB (talk) 13:13, 19 April 2018 (PDT)

Treatments

The below is super prescriptive – needs to be reframed so that it's not an instruction manual for how to self-treat. Also need to clean up the "doctor recommends" sections that have no citations and again, sound like treatment recommendations. --JenB (talk) 23:44, 22 April 2018 (PDT)

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Treatment is in a stepwise basis:

Step 1 - antihistamines and mast cell stabilizers + low-histamine diet

Step 2 - more antihistamines (including prescription variants) and mast cell stabilizers and benzodiazepines

Step 3 - cytotoxic treatments like Gleevec

Alternative/integrative treatments include vagus nerve-assisting practices (yoga, meditation); guided meditation for symptom control; frequency-specific microcurrent for revitalizing T1 helper cells and more. Because mast cell degranulation can be highly susceptible to stress, MCAS can become a vicious cycle, where the stress of the disease creates more symptoms of the disease.

Treatment must be begun incrementally, adding only one medication at a time until tolerated. Reactions to medication are often actually reactions to a filler - the solution to this is to order medications from a compounding pharmacy or to try alternative brands. Once the patient has H1 and H2 blockers as well as mast cell stabilizers safely on board, treatment must be done continuously for 6-8 weeks before any real effect is to be expected. Once there is improvement, the full protocol must be followed for at least 1 year before patient can attempt to reduce medication numbers.

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