Talk:Long COVID

Long COVID studies to add

• May, 2023, Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection
• Oct, 2022 Survey of Long COVID patients response to Nattokinase

• Aug, 2022, Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2

• Sep 2021, Post-COVID syndrome. A case series and comprehensive review
• May 2021, Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments

• Apr 2021, Long-COVID and Post-COVID Health Complications: An Up-to-Date Review on Clinical Conditions and Their Possible Molecular Mechanisms

• Sep 2021, Long-term side effects and lingering symptoms post COVID-19 recovery

• Jan 2021, Long Covid-19: Proposed Primary Care Clinical Guidelines for Diagnosis and Disease Management

"the overlap of the signs and symptoms they present with processes like fibromyalgia, chronic fatigue syndrome, or multiple chemical sensitivity is, medically, incontestable."

• Aug 2021, Post-COVID Syndrome: Incidence, Clinical Spectrum, and Challenges for Primary Healthcare Professionals

"There are five categories of long COVID-19 syndrome: Type 1 includes patients with varying duration of recovery that directly relates to the severity of infection, organ damage, and underlying medical conditions; Type 2 is characterized by symptoms persisting six weeks from the onset of illness; Type 3 shows a period of quiescence or nearly full recovery after initial infection, followed by a recurrence of symptoms that persist for at least three months (Type 3A) or at least six months (Type 3B); Type 4 includes patients who are initially asymptomatic at the time of a positive SARS-CoV-2 test but develop symptoms one to three months (Type 4A) or at least three months later (Type 4B), that persist for varying lengths of period; and Type 5 includes patients who have no or few symptoms at the time of a positive SARS-CoV-2 test and experience sudden death within the next 12 months"

• Feb 2021, A review of persistent post-COVID syndrome (PPCS)

"we have coined the umbrella term “persistent post-COVID syndrome” (PPCS) to describe the morbid post-ICU course of COVID survivors"

"compensatory anti-inflammatory response syndrome (CARS) occurs that leads to postinfectious/posttraumatic immunosuppression [8]. The purpose of the CARS response, a mirror-imaged counter-regulation to SIRS or systemic inflammatory response syndrome, is to dampen the proinflammatory state, prevent maladaptive multiple-organ dysfunction [9], and govern the return to immunologic homeostasis or normalcy [10]."

"excessive release of inflammatory cytokines such as interleukins 1, 6, 8, 17, and 1β, monocyte chemoattractant protein-1, and tissue necrosis factor α [11] collectively known as “cytokine storm”"

"Case report and systematic review suggest that children may experience similar long-term effects to adults after clinical COVID-19"

• Nov 2020, Case report and systematic review suggest that children may experience similar long-term effects to adults after clinical COVID-19

The five children with potential long COVID had a median age of 12 years (range 9–15) and four were girls. They had symptoms for 6–8 months after their clinical diagnoses of COVID-19. None were hospitalised at diagnosis, but one was later admitted for peri-myocarditis. All five children had fatigue, dyspnoea, heart palpitations or chest pain, and four had headaches, difficulties concentrating, muscle weakness, dizziness and sore throats. Some had improved after 6–8 months, but they all suffered from fatigue and none had fully returned to school. The systematic review identified 179 publications and 19 of these were deemed relevant and read in detail. None contained any information on long COVID in children.

Njt (talk) 01:42, September 30, 2021 (UTC)

References

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Date Order -- Loopy (talk) 17:52, November 6, 2020 (UTC)

The dates are in the wrong order. Should be oldest to newest.

I've sorted this for Notable studies. ~Njt (talk) 23:40, November 6, 2020 (UTC)

adverse reaction Any unintended or unwanted response to a treatment, whether in a clinical trial or licensed treatment. May be minor or serious.

homeostasis the maintenance of stable internal biological conditions (e.g. body temperature) in a changable environmen

cytokine any class of immunoregulatory proteins secreted by cells, especially immune cells. Cytokines are small proteins important in cell signaling that modulate the immune system. (Learn more: me-pedia.org)

α α / Α. Greek letter alpha or alfa (a symbol used in science), equivalent to "a".

cytokine storm an uncontrolled, sometimes life-threatening, excessive immune response, involving very high levels of proinflammatory cytokines and widespread tissue damage.