Citric acid cycle

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Overview of the citric acid cycle

The citric acid cycle (CAC) also known as the TCA cycle (tricarboxcylic acid cycle) or the Krebs cycle is a series of enzyme-catalyzed chemical reactions that allow for aerobic respiration to occur within the mitochondria of the cell. When this cycle or its associated parts[1] are not functioning properly subsequent fatigue may take place.

Citric acid cycle in ME/CFS[edit | edit source]

A 2016 paper started to define how and why people with ME/CFS might experience poorly functioning cellular respiration[2]while a review of published papers [3] added empirical evidence of a relationship between mitochondrial dysfunction and fatigue.

According to Ron Davis, speaking at the 2016 IACFS/ME conference, "ME/CFS patients have a marked decrease in some of the Citric Acid Cycle metabolites while mitochondrial mutations generally cause an increase."[4]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. "Pyruvate Dehydrogenase Complex". 
  2. Fluge, Øystein; Mella, Olav; Bruland, Ove; Risa, Kristin; Dyrstad, Sissel E.; Alme, Kine; Rekeland, Ingrid G.; Sapkota, Dipak; Røsland, Gro V. (Dec 22, 2016). "Metabolic profiling indicates impaired pyruvate dehydrogenase function in myalgic encephalopathy/chronic fatigue syndrome". JCI Insight. 1 (21). doi:10.1172/jci.insight.89376. ISSN 2379-3708. 
  3. Filler, Kristin; Lyon, Debra; Bennett, James; McCain, Nancy; Elswick, Ronald; Lukkahatai, Nada; Saligan, Leorey N. (Apr 13, 2014). "Association of mitochondrial dysfunction and fatigue: A review of the literature". BBA Clinical. 1: 12–23. doi:10.1016/j.bbacli.2014.04.001. ISSN 2214-6474. PMC 4136529Freely accessible. PMID 25147756. 
  4. "Open Medicine Foundation". Retrieved Oct 9, 2018. 
  5. "Krebs / citric acid cycle | Cellular respiration | Biology | Khan Academy". YouTube. Khan Academy. Dec 11, 2009. 

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

mitochondria - Important parts of the biological cell, with each mitochondrion encased within a mitochondrial membrane. Mitochondria are best known for their role in energy production, earning them the nickname "the powerhouse of the cell". Mitochondria also participate in the detection of threats and the response to these threats. One of the responses to threats orchestrated by mitochondria is apoptosis, a cell suicide program used by cells when the threat can not be eliminated.

metabolite - A chemical compound produced by, or involved in, metabolism. The term is often used to refer to the degradation products of drugs in the body.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.