Rosemary Underhill

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Rosemary A. Underhill, MB., B.S., is a Physician Consultant and a Fellow of Royal College of Surgeons.[1] Underhill trained as a physician, a surgeon and an obstetrician in London, England and was a medical student who witnessed the Royal Free Hospital outbreak in 1955.[2]

Underhill is a consultant and member of the board of Trustees of the New Jersey ME/CFS Association.

2017 Pediatric Primer[edit]

Dr. Underhill was one of the authors of the 2017 Pediatric Primer published in Frontiers in Pediatrics.

  • Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer (OPEN ACCESS/FULL TEXT). Authors: Peter C. Rowe, Rosemary A. Underhill, Kenneth J. Friedman, Alan Gurwitt, Marvin S. Medow, Malcolm S. Schwartz, Nigel Speight, Julian M. Stewart, Rosamund Vallings and Katherine S. Rowe
    Abstract:Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex disease that affects children and adolescents as well as adults. The etiology has not been established. While many pediatricians and other health-care providers are aware of ME/CFS, they often lack essential knowledge that is necessary for diagnosis and treatment. Many young patients experience symptoms for years before receiving a diagnosis. This primer, written by the International Writing Group for Pediatric ME/CFS, provides information necessary to understand, diagnose, and manage the symptoms of ME/CFS in children and adolescents. ME/CFS is characterized by overwhelming fatigue with a substantial loss of physical and mental stamina. Cardinal features are malaise and a worsening of symptoms following minimal physical or mental exertion. These post-exertional symptoms can persist for hours, days, or weeks and are not relieved by rest or sleep. Other symptoms include cognitive problems, unrefreshing or disturbed sleep, generalized or localized pain, lightheadedness, and additional symptoms in multiple organ systems. While some young patients can attend school, on a full or part-time basis, many others are wheelchair dependent, housebound, or bedbound. Prevalence estimates for pediatric ME/CFS vary from 0.1 to 0.5%. Because there is no diagnostic test for ME/CFS, diagnosis is purely clinical, based on the history and the exclusion of other fatiguing illnesses by physical examination and medical testing. Co-existing medical conditions including orthostatic intolerance (OI) are common. Successful management is based on determining the optimum balance of rest and activity to help prevent post-exertional symptom worsening. Medications are helpful to treat pain, insomnia, OI and other symptoms. The published literature on ME/CFS and specifically that describing the diagnosis and management of pediatric ME/CFS is very limited. Where published studies are lacking, recommendations are based on the clinical observations and practices of the authors.[3]


Hypothesis on the disease ME/CFS[edit]

Myalgic encephalomyelitis, chronic fatigue syndrome: An infectious disease - Medical Hypotheses December 2015 Volume 85, Issue 6, Pages 765–773

Clinical guides[edit]


  • 2006, Prevalence of Chronic Fatigue Syndrome and Chronic Fatigue Within Families of CFS Patients
    "Abstract - The prevalence of CFS (Chronic Fatigue Syndrome) and chronic fatigue were investigated in family members of CFS patients using a questionnaire-based study. Significant differences were seen between the prevalence of CFS in all groups of family members relative to the published community prevalence of 0.422% (spouses/partners: 3.2%, p < 0.001; offspring: 5.1%, p < .001; parents and siblings: 1.1%, p < 0.02; second and third degree blood relatives 0.8%, p < 0.02). The prevalence of CFS was higher in genetically unrelated household contacts and in nonresident genetic relatives than in the community, indicating that both household contact and genetic relationship are risk factors for CFS."[5]

Open letter to The Lancet[edit]

Two open letters to the editor of The Lancet urged the editor to commission a fully independent review of the PACE trial, which the journal had published in 2011. In 2016, Dr. Underhill, along with 41 colleagues in the ME/CFS field, signed the second letter.

CFSAC testimony[edit]

See also[edit]


  1. Rosemary Underhill - Zoom Information
  3. Rowe, Peter C.; Underhill, Rosemary A.; Friedman, Kenneth J.; Gurwitt, Alan; Medow, Marvin S.; Schwartz, Malcolm S.; Speight, Nigel; Stewart, Julian M.; Vallings, Rosamund; Rowe, Katherine S. (2017), "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Diagnosis and Management in Young People: A Primer", Frontiers in Pediatrics, 5 (121), doi:10.3389/fped.2017.00121 
  4. Oleske JJ. A Consensus Manual for the Primary Care and Management of Chronic Fatigue Syndrome. The Academy of Medicine of New Jersey, The New Jersey Department of Health & Senior Services; 2002.
  5. Rosemary A. Underhill & Ruth O'Gorman. (2006). Prevalence of Chronic Fatigue Syndrome and Chronic Fatigue Within Families of CFS Patients. Journal of Chronic Fatigue Syndrome, Vol. 13, Iss. 1, pp. 3-13.

The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history