Periodic paralysis

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Diagram of muscle channelopathies showing hypokalemic periodic paralysis on a spectrum of channelopathy diseases.
Periodic paralyses are types of muscle channelopathies.
Image: K June-Bum, 2014[1] CC-BY-NC-3.0

Periodic paralysis is a temporary paralysis of part of the body, with reoccurring episodes that last from minutes to hours.[2] There are different types of periodic paralysis, and it can be genetic (inherited) or acquired. Periodic paralysis conditions are types of muscle channelopathies, also known as myopathies.[1][3]

Types of periodic paralysis[edit | edit source]

Different types of periodic paralysis include:

Caused by low potassium.[3][4]
Caused by high potassium.[3][4]
Considered a variant of hyperkaleimic periodic paralysis, patients grow weaker when potassium levels rise.[4]
Linked to thyroid hormone levels.[4]
Caused by an inherited defect in a potassium channel, which affects both the heart and skeletal muscles. Patients with Andersen-Tawil Syndrome can experience heart rhythm disturbances even when their blood potassium is normal.[3][4]
Paramyotonia Congenita [4]

Periodic paralysis in ME/CFS[edit | edit source]

Some people with ME/CFS develop acquired periodic paralysis; the episodes of limb paralysis occur because of the ion transportation symptoms found in some people with ME/CFS.[5][6] Paralysis is not recognized in the International Consensus Primer, but the ion transport and channelopathy impairments that cause it are mentioned in the pathophysiology section, and the response to exercise section.[6]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.01.1 Kim, June-Bum (Jan 2014). "Channelopathies". Korean Journal of Pediatrics. 57 (1): 1–18. doi:10.3345/kjp.2014.57.1.1. ISSN 1738-1061. PMC 3935107Freely accessible. PMID 24578711. 
  2. Dissanayake, HA; Padmaperuma, PACD (Jul 18, 2018). "Periodic paralysis: what clinician needs to know?". Endocrinology & Metabolism International Journal. 6 (4). doi:10.15406/emij.2018.06.0018. ISSN 2473-0815. 
  3. Muscular Dystrophy Association. "Myopathies: Facts" (PDF). Retrieved Nov 29, 2018. 
  4. Periodic Paralysis International. "What is Periodic Paralysis?". Retrieved Jan 18, 2019. 
  5. Carruthers, Bruce M.; Jain, Anil Kumar; De Meirleir, Kenny L.; Peterson, Daniel L.; Klimas, Nancy G.; Lerner, A. Martin; Bested, Alison C.; Flor-Henry, Pierre; Joshi, Pradip; Powles, A C Peter; Sherkey, Jeffrey A.; van de Sande, Marjorie I. (2003), "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols" (PDF), Journal of Chronic Fatigue Syndrome, 11 (2): 7-115, doi:10.1300/J092v11n01_02 
  6. 6.06.1 Carruthers, BM; van de Sande, MI; De Meirleir, KL; Klimas, NG; Broderick, G; Mitchell, T; Staines, D; Powles, ACP; Speight, N; Vallings, R; Bateman, L; Bell, DS; Carlo-Stella, N; Chia, J; Darragh, A; Gerken, A; Jo, D; Lewis, DP; Light, AR; Light, KC; Marshall-Gradisnik, S; McLaren-Howard, J; Mena, I; Miwa, K; Murovska, M; Stevens, SR (2012), Myalgic encephalomyelitis: Adult & Paediatric: International Consensus Primer for Medical Practitioners (PDF), ISBN 978-0-9739335-3-6 

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.