Open letter to the Lancet

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On 13 November 2015, an open letter to the medical journal,The Lancet, was directed at its editor, Dr. Richard Horton, by six experts in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, calling for the PACE trial data to be independently reanalysed.[1] The Lancet published an article in on the PACE trial in 2011, Comparison of adaptive pacing therapy, cognitive behaviour therapy, graded exercise therapy, and specialist medical care for chronic fatigue syndrome (PACE): a randomized trial, in which claims made by the trial authors have since been shown to be in error after being sued to release the study's raw data.[2][3]

Following a lack of response, the open letter was submitted again three months later, this time with 42 signatories.[4] A third letter was sent 10 June 2018 and had 94 signatories.[5] The third letter was resent on July 9th, 2018 and had additional signatories which included Members of Parliament, the Countess of Mar, and patient advocacy organizations.[6]

Letters[edit | edit source]

Signatories[edit | edit source]

First letter[edit | edit source]

The first letter had 6 signatures: Ronald Davis, Jonathan Edwards, Leonard Jason, Bruce Levin, Vincent Racaniello, Arthur Reingold

Second letter[edit | edit source]

The second letter had 42 signatures: Ronald Davis, Jonathan Edwards, Leonard Jason, Bruce Levin, Vincent Racaniello, Arthur Reingold, Dharam Ablashi, James Baraniuk, Lisa Barcellos, Lucinda Bateman, David Bell, Alison Bested, Gordon Broderick, John Chia, Lily Chu, Derek Enlander, Mary Ann Fletcher, Kenneth Friedman, David Kaufman, Nancy Klimas, Charles Lapp, Susan Levine, Alan Light, Sonya Marshall-Gradisnik, Peter Medveczky, Zaher Nahle, James Oleske, Richard Podell, Charles Shepherd, Christopher Snell, Nigel Speight, Donald Staines, Philip Stark, Eleanor Stein, John Swartzberg, Ronald Tompkins, Rosemary Underhill, Rosamund Vallings, Michael VanElzakker, William Weir, Marcie Zinn, Mark Zinn

Third letter[edit | edit source]

The third letter had 94 signatures: Dharam Ablashi, Michael Allen, Christopher Armstrong, James Baraniuk, Lisa Barcellos, Lucinda Bateman, Molly Brown, Robin Callender Smith, John Chia, Lily Chu, Joan Crawford, Janet Dafoe, Todd Davenport, Ronald Davis, Lucy Dechene, Simon Duffy, Jonathan Edwards, Valerie Eliot Smith, Derek Enlander, Meredyth Evans, Kenneth Friedman, Robert Garry, Keith Geraghty, Simin Ghatineh, Ian Gibson, Mike Godwin, Rebecca Goldin, Alan Gurwitt, Geoffrey Hallmann, Maureen Hanson, Malcolm Hooper, Leonard Jason, Michael Kahn, Jon Kaiser, David Kaufman, Betsy Keller, Nancy Klimas, Andreas Kogelnik, Richard Kwiatek, Eliana Lacerda, Charles Lapp, Bruce Levin, Donald Lewis, Alan Light, Vincent Lombardi, Alex Lubet, Steven Lubet, David Marks, Sonya Marshall-Gradisnik, Marlon Maus, Neil McGregor, Patrick McKnight, Marvin Medow, Jose Montoya, Sarah Myhill, Luis Nacul, Heidi Nicholl, James Oleske, Elisa Oltra, Nigel Paneth, Richard Podell, Nicole Porter, Vincent Racaniello, Arthur Reingold, Peter Rowe, Michael Scott, Charles Shepherd, Christopher Snell, Nigel Speight, Donald Staines, Philip Stark, Eleanor Stein, Staci Stevens, Julian Stewart, Leonie Sugarman, John Swartzberg, Ronald Tompkins, Barbara True, Samuel Tucker, David Tuller, Rosemary Underhill, Derya Unutmaz, AM Uyttersprot, Rosamund Vallings, Linda van Campen, Mark VanNess, Mark Vink, Frans Visser, Tony Ward, William Weir, John Whiting, Sadie Whittaker, Carolyn Wilshire, Marcie Zinn

Response[edit | edit source]

There has not been a direct response to the letter from Richard Horton or The Lancet.

See also[edit | edit source]

References[edit | edit source]


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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history