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Nortriptyline is a tricyclic antidepressant.[1] It is also marketed under the brand names Aventyl and Pamelor.[1]

Theory[edit | edit source]

Potential uses[edit | edit source]

Nortriptyline is licensed for use for clinical depression, and may be used off-label for anxiety, insomnia or sleep problems, nerve pain or chronic pain.[2][3]

Evidence[edit | edit source]

A Cochrane review in 2015 found insufficient evidence to recommend nortriptyline for nerve pain in adults.[4]

The medical practitioners' primer for the International Consensus Criteria of myalgic encephalomyelitis suggests nortriptyline may be useful for pain in patients with ME/CFS, but suggests other drugs for sleep problems and secondary depression. There is more evidence for the use of nortriptyline in fibromyalgia.[5]

Risks and safety[edit | edit source]

Side effects can be severe.[5]

Costs and availability[edit | edit source]

Nortriptyline is an inexpensive prescription-only medicine.

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

α - Greek letter alpha or alfa (symbol)

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

adverse reaction - Any unintended or unwanted response to the treatment under investigation in a clinical trial.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.