Nitrogen hypothesis

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The nitrogen hypothesis or nitrogen metabolism hypothesis of ME/CFS was first proposed by Christopher Armstrong in 2018.[1]

Theory[edit | edit source]

According to the Open Medicine Foundation, the nitrogen hypothesis states that: "nitrogen-containing by-products of energy production accumulate more readily in the cells of people with ME / CFS, these nitrogen-containing by-products can be damaging to the cells and their process of producing energy".[1]

Evidence[edit | edit source]

In 2020, the Open Medicine Foundation announced that Christopher Armstrong had been awarded a grant to investigate the nitrogen hypothesis at the Open Medicine Foundation's ME/CFS Collaborative Research Center at Stanford University, run by the Dr. Ron Davis.[1]

In Aug 2020, the Open Medicine Foundation stated "Armstrong first noted increased usage of amino acids, which contains nitrogen, in the metabolism of people with ME/CFS while working at the University of Melbourne. He was the first to apply metabolomics to the field of ME/CFS, publishing his results in 2015. Metabolomics is the study of small molecules (metabolites) using common standards of detection that enable different studies to be comparative and additive."[1]

Treatment[edit | edit source]

None has been proposed yet.

Articles and blogs[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

metabolomics - The analysis of the chemical metabolism within cells, tissues or organisms. The term is often used to refer to the full set of metabolites found in a cell in a given environment.

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

metabolomics - The analysis of the chemical metabolism within cells, tissues or organisms. The term is often used to refer to the full set of metabolites found in a cell in a given environment.

metabolite - A chemical compound produced by, or involved in, metabolism. The term is often used to refer to the degradation products of drugs in the body.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.