Mirtazapine

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Mirtazapine, sold under the brand names Remeron and Remeron SolTab, is an atypical tetracyclic antidepressant which is used primarily in the treatment of depression.[1] In addition to its antidepressant properties, mirtazapine has anxiolytic, sedative, antiemetic, antiallergenic, and appetite stimulant effects and is sometimes used in the treatment of anxiety disorders, insomnia, nausea and vomiting, and to aid weight gain when desirable. It is taken by mouth.

A 2018 Cochrane Review reported that mirtazapine is unlikely to substantially reduce pain in people with fibromyalgia. A small number of people may experience some improvement (moderate pain relief, better sleep). Specifically, mirtazapine reduced pain by 30% or more in five out of 10 people but it was not better than placebo in reducing fatigue, depression, or improving health‐related quality of life. They found no benefit of mirtazapine over placebo for pain relief of 50% or greater.[2]

Uses[edit | edit source]

In a recent Cochrane study fibromyalgia patients mirtazapine has been found to use a useful sleep aid for sleep problems, to reduce pain intensity, and to reduce pain by 30% ina significant number of patients.[2] Mirtazapine was not found effective in reducing fibromyalgia pain by 50% and significant side effects occurred in some patients.[2]

Side Effects[edit | edit source]

More commonly reported ones are:

  • Sleepiness
  • Weight gain[1]

Less commonly reported ones are:

  • Elevated alanine aminotransferase[2]

It is not known whether mirtazepine is safe for use in children.[1]

Notable studies[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. 1.01.11.2 "Remeron: Side Effects, Dosage & Uses". Drugs.com. Retrieved Sep 24, 2020. 
  2. 2.02.12.22.32.4 Welsch, Patrick; Bernardy, Kathrin; Derry, Sheena; Moore, R. Andrew; Häuser, Winfried (2018). "Mirtazapine for fibromyalgia in adults". Cochrane Database of Systematic Reviews (8). doi:10.1002/14651858.CD012708.pub2. ISSN 1465-1858. 

adverse reaction - Any unintended or unwanted response to the treatment under investigation in a clinical trial.

adverse reaction - Any unintended or unwanted response to the treatment under investigation in a clinical trial.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.