Medicine sensitivities

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Medicine sensitivities or drug intolerance/sensitivity refers to an inability to tolerate the adverse effects of a medication, generally at therapeutic or subtherapeutic doses. Conversely, a patient is said to be "tolerating" a drug when they can tolerate its adverse effects. It is not to be confused with a drug allergy, which is a form of drug intolerance, but requires an immune-mediated component. It is also not to be confused with drug tolerance ("drug resistance," or tachyphylaxis) which refers to a lack of adverse effects even at higher than average doses. Some instances of drug intolerance are known to result from genetic variations in drug metabolism.[1]

It is a common problem for ME/CFS patients.

Symptom recognition[edit | edit source]

Many patients with ME/CFS are sensitive to medications. This is particularly true of any medication that acts on the central nervous system, such as sedating medications: therapeutic benefits can often be achieved at lower-than-standard doses. Patients with ME/CFS might tolerate or need only a fraction of the usual recommended doses for medications. After initial management with lower dosing, one or more gradual increases may be considered as necessary and as tolerated by the patient.[3]

Prevalence[edit | edit source]

  • In a 2001 Belgian study, 48.5% of patients meeting the Fukuda criteria and 54.8% of patients meeting the Holmes criteria, in a cohort of 2073 CFS patients, reported new sensitivities to food or drugs.[4]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

Centers for Disease Control and Prevention (CDC) - The Centers for Disease Control and Prevention is a U.S. government agency dedicated to epidemiology and public health. It operates under the auspices of the Department of Health and Human Services.

central nervous system (CNS) - One of the two parts of the human nervous system, the other part being the peripheral nervous system. The central nervous system consists of the brain and spinal cord, while the peripheral nervous system consists of nerves that travel from the central nervous system into the various organs and tissues of the body.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.