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James F. Mowbray is a British doctor and professor of immunopathology who was affiliated with St Mary's Hospital Medical School in London. He is well known for co-editing a textbook on myalgic encephalomyelitis (ME) as well as for his work on developing an enterovirus antigen assay using the 5D8/1 monoclonal antibody against enterovirus VP1. This assay was previously used to demonstrate the presence of viral protein in the blood and brain tissue of British ME patients, and more recently has been used by Dr. John Chia to demonstrate viral presence in various tissues and organs of United States ME patients.
Book[edit | edit source]
Media coverage[edit | edit source]
Professor James Mowbray makes a brief appearance in 1988 BBC Horizon documentary Believe Me (timecode 31:14), where he explains how he developed the VP1 protein test for enterovirus.
See also[edit | edit source]
List of enterovirus infection studies (the introduction to this article detail the VP1 protein test for enterovirus, developed by Prof Mowbray using a 5-D8/1 monoclonal antibody).
Enterovirus (refers to the VP1 protein test).
Non-cytolytic enterovirus (refers to the VP1 protein test).
References[edit | edit source]
- ↑ Post-viral Fatigue Syndrome (Myalgic Encephalomyelitis)
- ↑ Derivation and biochemical characterization of an enterovirus group-specific monoclonal antibody.
- ↑ Clinical and research application of an enterovirus group-reactive monoclonal antibody.
- ↑ "Infection may cause postviral syndrome". New Scientist. 117: 35. January 28, 1988.
assay 1. (verb) analysis (as of an ore or drug) to determine the presence, absence, or quantity of one or more components. 2. (noun) In biochemistry, any laboratory protocol used to test a sample for one or more qualities.
enterovirus A genus of RNA viruses which typically enter the body through the respiratory or gastrointestinal systems and sometimes spread to the central nervous system or other parts of the body, causing neurological, cardiac, and other damage. Since the first reports of myalgic encephalomyelitis (ME), enteroviruses have been suspected as a cause of ME. Enteroviruses have also been implicated as the cause of Type I diabetes, congestive heart failure, and other conditions. Enteroviruses include poliovirus, coxsackieviruses, and many others. New enteroviruses and new strains of existing enteroviruses are continuously being discovered. (Learn more: viralzone.expasy.org)
antibodies Antibody/immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.
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