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Hydroxyproline is an amino acid and a major component of collagen.[1] The formation of hydroxyproline is catalyzed via the enzyme procollagen-proline dioxygenase via a reaction that requires vitamin C.[citation needed]

High plasma hydroxyproline[edit | edit source]

Elevated plasma hydroxyproline is associated with increased risk of connective tissue injuries[2] and metabolic bone diseases, e.g. osteoporosis.[3]

ME/CFS[edit | edit source]

Elevated levels of hydroxyproline, a marker of collagen breakdown, was found by Wenzhong Xiao in the ME/CFS Severely Ill, Big Data Study.[4]Robert Naviaux’s work has suggested it as a possible biomarker for female ME/CFS patients.[5]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. "Definition of HYDROXYPROLINE". www.merriam-webster.com. Retrieved Nov 26, 2019. 
  2. Murguia, M.J.; Vailas, A.; Mandelbaum, B.; Norton, J.; Hodgdon, J.; Goforth, H.; Riedy, M. (Nov 1, 1988). "Elevated plasma hydroxyproline: A possible risk factor associated with connective tissue injuries during overuse". The American Journal of Sports Medicine. 16 (6): 660–664. doi:10.1177/036354658801600619. ISSN 0363-5465. 
  3. Mazzuoli, G.; Antonelli, R.; Minisola, S. (Sep 1985). "Clinical significance of free plasma hydroxyproline measurement in metabolic bone disease". Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie. 23 (9): 515–519. ISSN 0340-076X. PMID 4067520. 
  4. Xiao, Wenzhong; Open Medicine Foundation - OMF (Nov 7, 2018), Results from the Severely Ill Patient Study (SIPS), retrieved Jul 16, 2019 
  5. Gordon, Eric; Anderson, Wayne; Nathan, Neil; Baxter, Asha; Wang, Lin; Alaynick, William A.; Bright, A. Taylor; Li, Kefeng; Naviaux, Jane C. (Sep 13, 2016). "Metabolic features of chronic fatigue syndrome". Proceedings of the National Academy of Sciences. 113 (37): E5472–E5480. doi:10.1073/pnas.1607571113. ISSN 0027-8424. PMID 27573827. 

enzyme - a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.

ME/CFS - An acronym that combines myalgic encephalomyelitis with chronic fatigue syndrome. Sometimes they are combined because people have trouble distinguishing one from the other. Sometimes they are combined because people see them as synonyms of each other.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.