Fludrocortisone (brand name: Florinef) is a synthetic corticosteroid hormone used in treatment of postural hypotension and adrenal insufficiency, including Addison's disease. It is frequently used off-label as a treatment for postural orthostatic tachycardia syndrome (POTS) and orthostatic intolerance (OI). In adrenal insufficiency, it is generally taken together with hydrocortisone.
Use in chronic fatigue syndrome[edit | edit source]
*In 1998, a study by Phillip K. Peterson, et al, showed that low-dose fludrocortisone does not provide sufficient benefit to patients with chronic fatigue syndrome. Using the 36-Item Short-Form Health Survey, a reaction time test, and a treadmill exercise test, they found no observed improvement in the severity of any symptom. Likewise, blood pressure and heart rate readings were unaffected by treatment.
Side effects and drug interactions[edit | edit source]
Notable studies[edit | edit source]
- 1998, A preliminary placebo-controlled crossover trial of fludrocortisone for chronic fatigue syndrome.(Full Text)
See also[edit | edit source]
References[edit | edit source]
- Chrousos, George; Pavlaki, Aikaterini N.; Magiakou, Maria Alexandra (2000). De Groot, Leslie J.; Chrousos, George; Dungan, Kathleen; Feingold, Kenneth R.; Grossman, Ashley; Hershman, Jerome M.; Koch, Christian; Korbonits, Márta; McLachlan, Robert, eds. "Glucocorticoid Therapy and Adrenal Suppression". Endotext. South Dartmouth (MA): MDText.com, Inc. PMID 25905379 – via NCBI NLM NIH Bookshelf.
- LLC, Revolvy,. ""Fludrocortisone" on Revolvy.com". www.revolvy.com. Retrieved Aug 14, 2018.
- Peterson, Phillip K.; Pheley, Alfred; Schroeppel, Jill; Schenck, Carlos; Marshall, Paul; Kind, Allan; Haugland, J. Mark; Lambrecht, Lawrence J.; Swan, Suzanne (Apr 27, 1998). "A Preliminary Placebo-Controlled Crossover Trial of Fludrocortisone for Chronic Fatigue Syndrome". Archives of Internal Medicine. 158 (8): 908. doi:10.1001/archinte.158.8.908. ISSN 0003-9926.
- "Proposed Diagnostic Criteria for ME/CFS". nationalacademiesofmedicine.org. 2015.
- Wright Clayton, Ellen; Algeria, Margarita; Bateman, Lucinda; Chu, Lily; Cleeland, Charles; Davis, Ronald; Diamond, Betty; Ganiats, Theodore; Keller, Betsy (Mar 16, 2015). Nancy Klimas; A Martin Lerner; Cynthia Murlow; Benjamin Natelson; Peter Rowe; Michale Shelanski. "Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome". National Academy of Medicine Education: 107–119. doi:10.17226/19012 – via NAP.EDU.
- "Fludrocortisone Side Effects in Detail - Drugs.com". Drugs.com. Retrieved Aug 14, 2018.
- "Fludrocortisone Drug Interactions - Drugs.com". Drugs.com. Retrieved Aug 14, 2018.
postural orthostatic tachycardia syndrome (POTS) - A form of orthostatic intolerance where the cardinal symptom is excessive tachycardia due to changing position (e.g. from lying down to sitting up).
orthostatic intolerance (OI) - The development of symptoms when standing upright, where symptoms are relieved upon reclining. Patients with orthostatic intolerance have trouble remaining upright for more than a few seconds or a few minutes, depending upon severity. In severe orthostatic intolerance, patients may not be able to sit upright in bed. Orthostatic intolerance is often a sign of dysautonomia. There are different types of orthostatic intolerance, including postural orthostatic tachycardia syndrome (POTS).
chronic fatigue syndrome (CFS) - A fatigue-based illness. The term CFS was invented invented by the U.S. Centers for Disease Control as an replacement for myalgic encephalomyelitis (ME). Some view CFS as a neurological disease, others use the term for any unexplained long-term fatigue. Sometimes used as a the term as a synonym of myalgic encephalomyelitis, despite the different diagnostic criteria.
adverse reaction - Any unintended or unwanted response to the treatment under investigation in a clinical trial.
National Institutes of Health (NIH) - A set of biomedical research institutes operated by the U.S. government, under the auspices of the Department of Health and Human Services.
National Academy of Medicine (NAM) - An American non-profit, non-governmental organization which provides expert advice to governmental agencies on issues relating to biomedical science, medicine and health. Formerly known as the Institute of Medicine (IOM).