File:T-cells-ME-CFS.jpg

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T cell subset quantification in PBMC from people with ME/CFS, people with MS and healthy controls. Within the T cell gate (CD3+), the CD4+ and CD8 staining was characterised to calculate the proportion of (A) CD4+ T cells, (B) CD8+ T cells, (C) double positive CD4+CD8+ T cells, and (D) the ratio of CD4+:CD8+ T cells. (E) The proportion of T cells which expressed the γδ TCR within the CD3+ T cell population were determined. Key: Healthy controls (C), multiple sclerosis (MS), mild/moderate ME/CFS (ME-M), and severely affected ME/CFS (ME-S).

Author: (or citation)[edit | edit source]

Cliff JM, King EC, Lee J-S, Sepúlveda N, Wolf A-S, Kingdon C, Bowman E, Dockrell HM, Nacul L, Lacerda E and Riley EM (2019) Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Front. Immunol. 10:796. doi: 10.3389/fimmu.2019.00796

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https://www.frontiersin.org/articles/10.3389/fimmu.2019.00796/full

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T cell A type of white blood cell which is mostly produced or matured in the thymus gland (hence T-cell) and is involved in the adaptive immune response on a cellular level. Also known as a T lymphocyte. (Learn more: www.youtube.com)

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

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current13:27, June 27, 2020Thumbnail for version as of 13:27, June 27, 20201,084 × 553 (212 KB)Notjusttired (talk | contribs)==== Title: (or description) ==== T cell subset quantification in PBMC from people with ME/CFS, people with MS and healthy controls. Within the T cell gate (CD3+), the CD4+ and CD8 staining was characterised to calculate the proportion...

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