File:Kynurenine pathway.jpg

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Kynurenine_pathway.jpg ‎(561 × 569 pixels, file size: 196 KB, MIME type: image/jpeg)

The Kynurenine pathway. IDO catabolizes indole compounds, including Trp and 5-hydroxytryptamine. Enzymes (blue) downstream of IDO generate bioactive catabolites called kynurenines. Immune and CNS cells express sensors (red) that detect these metabolic changes to impact immunologic and neurologic processes.

Citation: Mellor AL, Lemos H and Huang L (2017) Indoleamine 2,3-Dioxygenase and Tolerance: Where Are We Now? Front. Immunol.8:1360. doi: 10.3389/fimmu.2017.01360 Source: https://www.frontiersin.org/articles/10.3389/fimmu.2017.01360/full

Licensing[edit | edit source]

Creative Commons
attribution 		This file is licensed under the Creative Commons Attribution 4.0 International license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

enzyme a substance produced by a living organism which acts as a catalyst to bring about a specific biochemical reaction.

indoleamine (IDO) - any derivatives of an indole (e.g., serotonin, tryptophan) that contain an amine group

indole (IDO) - a signalling molecule produced by bacteria as a result of metabolising tryptophan, found in the intestines

central nervous system (CNS) - One of the two parts of the human nervous system, the other part being the peripheral nervous system. The central nervous system consists of the brain and spinal cord, while the peripheral nervous system consists of nerves that travel from the central nervous system into the various organs and tissues of the body.

indoleamine (IDO) - any derivatives of an indole (e.g., serotonin, tryptophan) that contain an amine group

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current14:06, June 12, 2019Thumbnail for version as of 14:06, June 12, 2019561 × 569 (196 KB)Notjusttired (talk | contribs)

You cannot overwrite this file.

The following page uses this file:

Metadata

This file contains additional information, probably added from the digital camera or scanner used to create or digitize it.

If the file has been modified from its original state, some details may not fully reflect the modified file.

Retrieved from "https://me-pedia.org/w/index.php?title=File:Kynurenine_pathway.jpg&oldid=59757"