File:Flow cytometry MAIT ME CFS.jpg

Summary[edit | edit source]

Title: (or description)[edit | edit source]

Mucosal Associated Invariant T cells in peripheral blood of people with ME/CFS, people with MS and healthy controls. By flow cytometry, within the CD3+γδTCR− T cell population (A), MAIT cells were identified as Vα7.2+CD161++ in PBMC B: MAIT cells were further characterised based on CD4+ or CD8+ expression C, D: The proportion of T cells which were MAIT cells in. E: The proportion of MAIT cells which were CD8+ is shown for each individual. A–C: Data from one representative severely affected ME/CFS patient. D,E: Data are from C

• • P < 0.01, ***P < 0.001, ****P < 0.0001. (F) ROC curve analysis of proportions of the CD3+γδTCR− T cell population which were MAIT cells for the different patient groups relative to the Healthy Controls.

G: ROC curve analysis of proportions of MAIT cells which were CD8+ for the different patient groups relative to the Healthy Controls. D, E: Data from healthy controls (C), multiple sclerosis (MS), mild/moderate ME/CFS (ME-M), and severely affected ME/CFS (ME-S). AUC: Area Under the Curve.

Author: (or citation)[edit | edit source]

Cliff JM, King EC, Lee J-S, Sepúlveda N, Wolf A-S, Kingdon C, Bowman E, Dockrell HM, Nacul L, Lacerda E and Riley EM (2019) Cellular Immune Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Front. Immunol. 10:796. doi: 10.3389/fimmu.2019.00796

Figure 6

Source: (e.g. internet address)[edit | edit source]

https://www.frontiersin.org/articles/10.3389/fimmu.2019.00796/full

Other information:[edit | edit source]

See also[edit | edit source]

• List of abnormal findings in chronic fatigue syndrome and myalgic encephalomyelitis
• Severe and very severe ME

Licensing[edit | edit source]

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