Carl-Gerhard Gottfries

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Source:Erik Nilsson

Carl-Gerhard Gottfries, MD, PhD, is a Swedish professor, ME/CFS doctor, and founder of the Gottfries Clinic, Mölndal, Sweden. After developing chronic fatigue syndrome following a case of the flu, he discovered that monthly injections of a staphylococcus aureus vaccine boosted his immune system, successfully allowing him to return to work. He has continued using a staphylococcus vaccine injection every month for over fifty years.[1]

Clinic[edit | edit source]

Gottfries Clinic AB (Gottfriesmottagningen), was previously financed through the health-care system, but now is privately operated. It is a specialty clinic for the 1) evaluation, diagnosis and treatment of patients with fibromyalgia and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), chronic fatigue and widespread muscular pain, and 2) research for developing and treatment for such patients. Located at Krokslätts Torg 5, Mölndal, Sweden.[2]

2017 Ramsay Award[edit | edit source]

A team comprised of Dr. Jonas Bergquist and Dr. Jonas Blomberg of Uppsala University and Dr. Carl-Gerhard Gottfries and Dr. Olof Zachrisson of the Gottfries Clinic were awarded a 2017 Ramsay Award grant from the Solve ME/CFS Initiative for research into biomarkers for initiation (infection) and metabolic derangement in ME/CFS.[3]

Talks and interviews[edit | edit source]

Notable studies[edit | edit source]

  • 2020, Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts[17] - (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. "Carl-Gerhard Gottfries: A Swedish Chronic Fatigue Syndrome Story".
  4. Regland, B; Andersson, M; Abrahamsson, L; Bagby, J; Dyrehag, LE; Gottfries, CG (1997). "Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome". Scandinavian Journal of Rheumatology. 26 (4): 301–7. PMID 9310111.
  5. Andersson, M; Bagby, JR; Dyrehag, L; Gottfries, C (1998). "Effects of staphylococcus toxoid vaccine on pain and fatigue in patients with fibromyalgia/chronic fatigue syndrome". European Journal of Pain. 2 (2): 133–142. PMID 10700309.
  6. Regland, Bjorn; Zachrisson, Olof; Stejskal, Vera; Gottfries, Carl Gerhard (2000). "Immunotherapy of Chronic Fatigue Syndrome: Therapeutic Interventions Aimed at Modulating the Th1/Th2 Cytokine Expression Balance". Journal of Chronic Fatigue Syndrome. 8 (1): 57–65. doi:10.1300/J092v08n01_04.
  7. Zachrisson, O; Regland, B; Jahreskog, M; Kron, M; Gottfries, CG (June 2002). "A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale)". J Psychosomatic Research. 52 (6): 501–9. PMID 12069875.
  8. Zachrisson, O; Colque-Navarro, P; Gottfries, CG; Regland, B; Möllby, R (February 2004). "Immune modulation with a staphylococcal preparation in fibromyalgia/chronic fatigue syndrome: relation between antibody levels and clinical improvement". European Journal of Clinical Microbiology & Infectious Disease. 23 (2): 98–105. doi:10.1007/s10096-003-1062-8.
  9. Carl-Gerhard Gottfries, Ove Häger, Björn Regland & Olof Zachrisson. (2006). Long-Term Treatment with a Staphylococcus Toxoid Vaccine in Patients with Fibromyalgia and Chronic Fatigue Syndrome. Journal of Chronic Fatigue Syndrome, Vol. 13, Iss. 4, pp. 29-40. DOI:10.1300/J092v13n04_04
  10. Elfaitouri, A; Shao, X; Mattsson Ulfstedt, J; Muradrasoli, S; Bölin Wiener, A; Golbob, S; Ohrmalm, C; Matousek, M; Zachrisson, O; Gottfries, C-G; Blomberg, J (2011), "Murine gammaretrovirus group G3 was not found in Swedish patients with myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia.", PLoS One, 6 (10), doi:10.1371/journal.pone.0024602
  11. Blomberg, Jonas; Blomberg, Fredrik; Sjösten, Anna; Sheikholvaezin, Ali; Bölin-Wiener, Agnes; Elfaitouri, Amal; Hessel, Sanna; Gottfries, Carl-Gerhard; Zachrisson, Olof; Öhrmalma, Christina; Jobs, Magnus; Pipkorn, Rüdiger (2012), "No Evidence for Xenotropic Murine Leukemia-Related Virus Infection in Sweden Using Internally Controlled Multiepitope Suspension Array Serology", Clinical and Vaccine Immunology, 19 (9): 1399-1410, doi:10.1128/CVI.00391-12
  12. Elfaitouri, A; Herrmann, B; Bölin-Wiener, A; Wang, Y; Gottfries, C-G; Zachrisson, O; Pipkorn, R; Rönnblom, L; Blomberg, J (2013), "Epitopes of Microbial and Human Heat Shock Protein 60 and Their Recognition in Myalgic Encephalomyelitis", PLoS One, 8 (11), doi:10.1371/journal.pone.0081155
  13. Regland, Björn; Forsmark, Sara; Halaouate, Lena; Matousek, Michael; Peilot, Birgitta; Zachrisson, Olof; Gottfries, Carl-Gerhard (2015), "Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia.", PLoS ONE, 10 (4), doi:10.1371/journal.pone.0124648
  14. Blomberg, Jonas; Gottfries, Carl-Gerhard; Elfaitouri, Amal; Rizwan, Muhammad; Rosén, Anders (2018), "Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model", Frontiers in Immunology, 2018 (9): 229, doi:10.3389/fimmu.2018.00229
  15. Nilsson, MKL; Zachrisson, O; Gottfries, C; Matousek, M; Peilot, B; Forsmark, S; Schuit, RC; Carlsson, ML; Kloberg, A; Carlsson, A (June 2018). "A randomised controlled trial of the monoaminergic stabiliser (-)-OSU6162 in treatment of myalgic encephalomyelitis/chronic fatigue syndrome". Acta Neuropsychiatrica. 30 (3): 148–157. doi:10.1017/neu.2017.35. PMID 29212562.
  16. Blomberg, Jonas; Rizwan, Muhammad; Böhlin-Wiener, Agnes; Elfaitouri, Amal; Julin, Per; Zachrisson, Olof; Rosén, Anders; Gottfries, Carl-Gerhard. "Antibodies to Human Herpesviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients". Frontiers in Immunology. doi:10.3389/fimmu.2019.01946.
  17. Bynke, Annie; Julin, Per; Gottfries, Carl-Gerhard; Heidecke, Harald; Scheibenbogen, Carmen; Bergquist, Jonas (August 1, 2020). "Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients – A validation study in plasma and cerebrospinal fluid from two Swedish cohorts". Brain, Behavior, & Immunity - Health. 7: 100107. doi:10.1016/j.bbih.2020.100107. ISSN 2666-3546.

antibodies Antibody/immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.

randomized controlled trial (RCT) - A trial in which participants are randomly assigned to two groups, with one group receiving the treatment being studied and a control or comparison group receiving a sham treatment, placebo, or comparison treatment.

antibodies Antibody/immunoglobulin refers to any of a large number of specific proteins produced by B cells that act against an antigen in an immune response.

myalgic encephalomyelitis (M.E.) - A disease often marked by neurological symptoms, but fatigue is sometimes a symptom as well. Some diagnostic criteria distinguish it from chronic fatigue syndrome, while other diagnostic criteria consider it to be a synonym for chronic fatigue syndrome. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. PEM can last for days or weeks. Symptoms can include cognitive impairments, muscle pain (myalgia), trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, among others. An estimated 25% of those suffering from ME are housebound or bedbound. The World Health Organization (WHO) classifies ME as a neurological disease.

autoantibody An antibody that works against the body's own antigens, a hallmark of autoimmune diseases. Autoantibodies are the opposite of an antibodies.

β β / Β. Greek letter beta (a symbol used in science), equivalent to "b".

somatic symptom disorder A psychiatric term to describe an alleged condition whereby a person's thoughts somehow cause physical symptoms. The actual existence of such a condition is highly controversial, due to a lack of scientific evidence. It is related to other psychiatric terms, such as "psychosomatic", "neurasthenia", and "hysteria". Older terms include "somatization", "somatoform disorder", and "conversion disorder". Such terms refer to a scientifically-unsupported theory that claims that a wide range of physical symptoms can be created by the human mind, a theory which has been criticized as "mind over matter" parapsychology, a pseudoscience.

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From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.