It has been studied for its possible benefits in inflammatory bowel diseases (IBDs), such as ulcerative colitis (UC) and Crohn’s disease (CD), the mucosal immune system, intestinal motility, hemoglobinopathies, genetic metabolic diseases, hypercholesterolemia, obesity and insulin resistance, and ischemic stroke.
Butyrate is a histamine agonist.
It decreases intestinal permeability.
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References[edit | edit source]
- Canani, Roberto Berni; Costanzo, Margherita Di; Leone, Ludovica; Pedata, Monica; Meli, Rosaria; Calignano, Antonio (Mar 28, 2011), "Potential beneficial effects of butyrate in intestinal and extraintestinal diseases", World Journal of Gastroenterology : WJG, 17 (12): 1519–1528, doi:10.3748/wjg.v17.i12.1519, ISSN 1007-9327, PMC , PMID 21472114, retrieved Nov 9, 2016
- Kemp, S.; Wei, H. M.; Lu, J. F.; Braiterman, L. T.; McGuinness, M. C.; Moser, A. B.; Watkins, P. A.; Smith, K. D. (November 1998), "Gene redundancy and pharmacological gene therapy: implications for X-linked adrenoleukodystrophy", Nature Medicine, 4 (11): 1261–1268, doi:10.1038/3242, ISSN 1078-8956, PMID 9809549
- Alvaro, Adriana; Solà, Rosa; Rosales, Roser; Ribalta, Josep; Anguera, Anna; Masana, Lluís; Vallvé, Joan Carles (November 2008), "Gene expression analysis of a human enterocyte cell line reveals downregulation of cholesterol biosynthesis in response to short-chain fatty acids", IUBMB life, 60 (11): 757–764, doi:10.1002/iub.110, ISSN 1521-6551, PMID 18642346
agonist - A chemical that binds to the receptor and stimulates it's function, e.g., morphine is an opioid agonist that binds to the opioid receptor, reducing pain. The opposite of an antagonist.
α - Greek letter alpha or alfa (symbol)