Physical changes at high altitude after full acclimatization has been achieved include reduced production of lactate post-exercise, increased tissue carbon dioxide, increased red blood cell mass, increased hematocrit, decreased plasma volume, a higher concentration of capillaries in skeletal muscles, increased myoglobin, increased mitochondria, increased aerobic enzyme concentration, increase in 2,3-Bisphosphoglyceric acid, hypoxic pulmonary vasoconstriction, and right ventricular hypertrophy.
The decreased lactate production at altitude is called the "lactate paradox."
References[edit | edit source]
- Hochachka, P. W.; Beatty, C. L.; Burelle, Y.; Trump, M. E.; McKenzie, D. C.; Matheson, G. O. (Jun 1, 2002), "The Lactate Paradox in Human High-Altitude Physiological Performance", Physiology, 17 (3): 122–126, ISSN 1548-9213, PMID 12021383, retrieved Nov 9, 2016