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S-adenosyl-methionine, also known as ADE-SD4, Ademetionine, S-adenosylmethionine, and abbreviated AdoMet or SAMe,[1] is an amino acid derivative synthesized in the body that acts as the body's main methyl donor in many different metabolic reactions. It may become depleted with B-vitamin deficiency, chronic inflammation, and has been observed to decrease with age.[citation needed] When a person is deficient in

Theory[edit | edit source]

SAMe may help people with ME or CFS by restoring methyl donor levels, allowing methylation reactions to continue at a normal rate. If there is a deficiency of methyl donors in the central nervous system, SAMe supplementation might be expected to improve some brain function, or improve mood. Among many other synthetic reactions, SAMe aids in the synthesis of the neurotransmitters norepinephrine, dopamine, and serotonin.

Evidence[edit | edit source]

A small number of studies have been conducted in fibromyalgia patients which showed some positive effects when taking SAMe.[2][3][4][5] The main positive effect has been described as a reduction in pain levels.[5] However, Volkmann et al (2009) found no significant effect in a ten day trial of fibromyalgia patients.[6]

Risks and safety[edit | edit source]

Costs and availability[edit | edit source]

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. "SAMe Uses, Benefits & Dosage - Herbal Database". Retrieved Oct 15, 2019. 
  2. Di Benedetto, P.; Iona, L. G.; Zidarich, V. (Feb 1, 1993). "Clinical evaluation of S-adenosyl-L-methionine versus transcutaneous electrical nerve stimulation in primary fibromyalgia". Current Therapeutic Research. 53 (2): 222–229. doi:10.1016/S0011-393X(05)80250-4. ISSN 0011-393X. 
  3. Jacobsen, S.; Danneskiold-Samsøe, B.; Andersen, R. B. (1991). "Oral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation". Scandinavian Journal of Rheumatology. 20 (4): 294–302. doi:10.3109/03009749109096803. ISSN 0300-9742. PMID 1925418. 
  4. Tavoni, A.; Vitali, C.; Bombardieri, S.; Pasero, G. (Nov 20, 1987). "Evaluation of S-adenosylmethionine in primary fibromyalgia. A double-blind crossover study". The American Journal of Medicine. 83 (5A): 107–110. doi:10.1016/0002-9343(87)90862-x. ISSN 0002-9343. PMID 3318438. 
  5. 5.05.1 Edwards, A. M.; Blackburn, L.; Christie, S.; Townsend, S.; David, J. (Jan 1, 2000). "Food Supplements in the Treatment of Primary Fibromyalgia: A Double-blind, Crossover Trial of Anthocyanidins and Placebo". Journal of Nutritional & Environmental Medicine. 10 (3): 189–199. doi:10.1080/13590840050134863. ISSN 1359-0847. 
  6. Volkmann, H.; Norregaard, J.; Jacobsen, S.; Danneskiold-samsøe, B.; Knoke, G.; Nehrdich, D. (Jan 1, 1997). "Double-blind, Placebo-controlled Cross-over Study of Intravenous S-Adenosyl-L-Methionine in Patients with Fibromyalgia". Scandinavian Journal of Rheumatology. 26 (3): 206–211. doi:10.3109/03009749709065682. ISSN 0300-9742. 

central nervous system (CNS) - One of the two parts of the human nervous system, the other part being the peripheral nervous system. The central nervous system consists of the brain and spinal cord, while the peripheral nervous system consists of nerves that travel from the central nervous system into the various organs and tissues of the body.

The information provided at this site is not intended to diagnose or treat any illness.
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history.