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5-Hydroxytryptophan (5-HTP) is a precursor to the neurotransmitter serotonin.[1]

The reaction that causes 5-HTP to become serotonin requires the action of the enzyme aromatic-L-amino-acid decarboxylase (AADC). Vitamin B6 is also required as a cofactor.[1] The same enzyme catalyzes a number of other reactions,[1] including:

5-HTP has been shown to increase serotonin levels in the central nervous system.[2]

Reports about serotonin levels in ME/CFS patients are mixed. One study hypothesized, based off of their findings on tryptophan, that ME/CFS patients fell into two groups: a group with high brain serotonin, and a group with normal serotonin.[3] Multiple studies have found high, low, or normal serotonin, due either to different diagnostic criteria or ME/CFS subgroups.[3]

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References[edit | edit source]

  1. 1.0 1.1 1.2 "AADC". Human Metabolome database. Retrieved 1 May 2018. 
  2. Turner, Erick H; Loftis, Jennifer M; Blackwell, Aaron D (2006). "Serotonin a la carte: Supplementation with the serotonin precursor5-hydroxytryptophan". Pharmacology & Therapeutics. 109 (3). 
  3. 3.0 3.1 Badawy AAB, AAB; Morgan, CJ; Llewelyn, MB; Albuquerque, SRJ; Farmer, A (2005). "Heterogeneity of serum tryptophan concentration and availability to the brain in patients with the chronic fatigue syndrome". Journal of Psychopharmacology. 19 (4): 385–391. 

The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history