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Wirth-Scheibenbogen hypothesis
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Prof Dr [[Klaus Wirth]] and Prof Dr [[Carmen Scheibenbogen]] ==Theory== ===Hypothesis === [[Endothelial dysfunction]] is proposed to be key to ME/CFS, which is regarded as a neurovascular disease.<ref name="Wirth2020a"/><ref name="Wirth2021a"/><ref name="Wirth2021b"/> ==Evidence== ==Treatment== Self-administered [[Immunoglobulin G]] (IgG) is a proposed treatment, with a proof of concept trial completed in 2021.<ref name="Scheibenbogen2021a"/> ==Notable studies == *2021, An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome<ref name="Wirth2021b">{{Cite journal | last =Wirth| first = Klaus J.|author-link = | last2 = Scheibenbogen | first2=Carmen | author-link2 = Carmen Scheibenbogen | last3 = Paul | first3 = Friedemann | author-link3 = | date = 2021-11-22 | title = An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|url=https://doi.org/10.1186/s12967-021-03143-3|journal=Journal of Translational Medicine|volume=19|issue=1|pages=471|doi=10.1186/s12967-021-03143-3|issn=1479-5876|pmc=PMC8607226|pmid=34809664|access-date=|quote=|via=}}</ref> - [https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-03143-3 (Full text)] *2021, Pathophysiology of skeletal muscle disturbances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)<ref name="Wirth2021a">{{Cite journal | last =Wirth| first = Klaus J. | author-link = Klaus Wirth | last2 = Scheibenbogen | first2=Carmen | author-link2 = Carmen Scheibenbogen | date = 2021-04-21 | title = Pathophysiology of skeletal muscle disturbances in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)|url=https://doi.org/10.1186/s12967-021-02833-2|journal=Journal of Translational Medicine|volume=19|issue=1|pages=162|doi=10.1186/s12967-021-02833-2|issn=1479-5876|pmc=PMC8058748|pmid=33882940}}</ref> - [https://doi.org/10.1186/s12967-021-02833-2 (Full text)] *2021, Tolerability and Efficacy of s.c. IgG Self-Treatment in ME/CFS Patients with IgG/IgG Subclass Deficiency: A Proof-of-Concept Study<ref name="Scheibenbogen2021a">{{Cite journal | last =Scheibenbogen | first = Carmen | author-link = Carmen Scheibenbogen | last2 = Sotzny | first2 = Franziska | author-link2 = Franziska Sotzny | last3 = Hartwig | first3 = Jelka | author-link3 = | last4 = Bauer | first4=Sandra | authorlink4 = Sandra Bauer | last5 = Freitag | first5 = Helma | authorlink5 = Helma Freitag|last6 = Wittke | first6 = Kirsten | authorlink6 = | last7 = Doehner | first7 = Wolfram | last8 = Scherbakov | first8 = Nadja|last9 = Loebel | first9 = Madlen | last10 = Grabowski | first10 = Patricia Grabowski | authorlink10 = Patricia Grabowski| date = Jan 2021 | title = Tolerability and Efficacy of s.c. IgG Self-Treatment in ME/CFS Patients with IgG/IgG Subclass Deficiency: A Proof-of-Concept Study|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198960/|journal=Journal of Clinical Medicine|language=en|volume=10|issue=11|pages=2420|doi=10.3390/jcm10112420|pmc=PMC8198960|pmid=34072494|access-date=|quote=|via=}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198960/ (Full text)] *2020, A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against Γ2-adrenergic receptors<ref name="Wirth2020a">{{Cite journal | last =Wirth| first = Klaus | authorlink = Klaus Wirth | last2 = Scheibenbogen | first2=Carmen | author-link2 = Carmen Scheibenbogen | date = 2020-06-01 | title = A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against Γ2-adrenergic receptors|url=https://www.sciencedirect.com/science/article/pii/S1568997220300823|journal=Autoimmunity Reviews|language=en|volume=19|issue=6|pages=102527|doi=10.1016/j.autrev.2020.102527|issn=1568-9972}}</ref> - [https://doi.org/10.1016/j.autrev.2020.102527 (Full text)] ===Evidence and related studies === *2012, Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls<ref name="WhiteAT2012">{{Cite journal | last1 = White | first1 = Andrea T | authorlink1 = Andrea White | last2 = Light | first2 = Alan R | authorlink2 = Alan Light | last3 = Hughen | first3 = Ronald W | authorlink3 = Ronald Hughen | last4 = VanHaitsma | first4 =Timothy A | authorlink4 = Timothy VanHaitsma | last5 = Light | first5 = Kathleen C | authorlink5 = Kathleen Light | title = Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls | journal = Psychosom Med | volume = 74 | issue = 1 | page = 46-54 | date = Dec 30, 2011 | pmid = 22210239 | doi = 10.1097/PSY.0b013e31824152ed | url = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256093/}}</ref> - [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3256093/ (Full text)] *2011, Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome<ref name="LightAR2011">{{Cite journal | last1 = Light | first1 = Alan R | authorlink1 = Alan Light | last2 = Bateman | first2 = Lucinda | authorlink2 = Lucinda Bateman | last3 = Jo | first3 = Daehyun | authorlink3 = Daehyun Jo | last4 = Hughen | first4 = Ronald W | authorlink4 = Ronald Hughen | last5 = Vanhaitsma | first5 = TA | authorlink5 = Timothy VanHaitsma | last6 = White | first6 = Andrea T | authorlink6 = Andrea White | last7 = Light | first7 = Kathleen C | authorlink7 = Kathleen Light | title = Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome | journal = J Intern Med | volume = 271 | issue = 1 | page = 64-81 | date = Jul 13, 2011 | pmid = 21615807 | doi = 10.1111/j.1365-2796.2011.02405.x | url = http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2796.2011.02405.x/abstract }}</ref> - [http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2796.2011.02405.x/abstract (Abstract)] *2009, Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects<ref name="LightAR2009">{{Cite journal | last1 = Light | first1 = Alan R | authorlink1 = Alan Light | last2 = White | first2 = Andrea T | authorlink2 = Andrea White | last3 = Hughen | first3 = Ronald W | authorlink3 = Ronald Hughen | last4 = Light | first4 = Kathleen C | authorlink4 = Kathleen Light | title = Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects| journal = J Pain | volume = 10 | issue = 10 | page = 1099-112 | date = Jul 31, 2009 | pmid = 19647494 | doi = 10.1016/j.jpain.2009.06.003 | url = http://www.jpain.org/article/S1526-5900(09)00574-4/abstract}}</ref> - [http://www.jpain.org/article/S1526-5900(09)00574-4/abstract (Abstract)] ==See also== *[[Endothelial dysfunction]] *[[Beta 2-adrenergic receptor]]/[[Γ2-adrenergic receptor]] (Γ2AdR) *[[Alpha 2-adrenergic receptor|Alpha 2-adrenergic receptors/Ξ±2-adrenergic receptor]]s (a2AdR) *[[Klaus Wirth]] *[[Carmen Scheibenbogen]] ==Learn more== ==References== {{reflist}} [[Category:Medical hypotheses]]
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