Vitamin D receptor
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
The Vitamin D receptor (VDR) is a cell receptor that turns on the expression of certain pathways when activated by Vitamin D.
Individuals who are heterozygous or homozygous for the VDR mutation have lower Vitamin D levels, make less dopamine, and are more tolerant of methyl donors.
VDR may be required for the normal development of natural killer T cells that react to cells expressing CD1d, as in cells infected by certain viruses.[1]
An Epstein barr virus protein EBNA-3 has an affinity for VDR and may actually block the activation of VDR-dependent genes by Vitamin D.[2]
