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Vitamin D
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== ME/CFS == A retrospective study found patients with CFS have lower levels of Vitamin D than the general population. However, it was uncertain whether this is correlated with the amount of time CFS patients spend indoors or with some other factor.<ref name="berkovitz2013">{{Cite journal | doi = 10.1024/0300-9831.79.4.250| issn = 0300-9831| volume = 79 | issue = 4| pages = 250β254| last1 = Berkovitz | first1 = Saul | authorlink = Saul Berkovitz | last2 = Ambler | first2 = Gareth | last3 = Jenkins | first3 = Michael | last4 = Thurgood | first4 = Sue| title = Serum 25-hydroxy Vitamin D Levels in Chronic Fatigue Syndrome: a Retrospective Survey| journal = International Journal for Vitamin and Nutrition Research| date = 2009-07-01| url = http://econtent.hogrefe.com/doi/abs/10.1024/0300-9831.79.4.250}}</ref><ref name="abokrysha2012">{{Cite journal | doi = 10.1111/j.1526-4637.2011.01304.x| issn = 1526-4637| volume = 13 | issue = 3| pages = 452β458| last = Abokrysha | first = Noha T.| title = Vitamin D deficiency in women with fibromyalgia in Saudi Arabia| journal = Pain Medicine (Malden, Mass.)| date = March 2012 | pmid = 22221390 | url = https://academic.oup.com/painmedicine/article/13/3/452/1852088}}</ref> Raising Vitamin D levels has reportedly resulted in remission for some CFS patients.<ref name="IACFSME">[https://iacfsme.org/PDFS/Attachment-E-Annedore-Hoeck,-Vitamin-D.aspx IACFS/ME - Vitamin D deficiency results in chronic fatigue and multi-system symptoms]</ref> Recent research has found no toxicity at 10,000 IU per day and levels as high as 15,000 IU/day are probably tolerated.{{citation needed | date = 2022}} At this dosage it will take 75-90 before symptom improvement is expected to be seen. Some people have seen some symptoms improved within days, but those are likely a small minority.{{Citation needed}} In 2015, Witham et al. found that high-dose oral vitamin D3 did not improve markers of vascular health or fatigue in patients with [[chronic fatigue syndrome]]. The study consisted of patients meeting the the [[Fukuda criteria]] (1994) for CFS and the [[Canadian Consensus Criteria|Canadian (2003) ME/CFS criteria]] who were either given 100,000 units oral vitamin D3 or a matching placebo every 2 months for 6 months.<ref name="Witham2015" /> In 2017, a study by Earl et al. concluded that low serum concentrations of total 25(OH)D do not appear to be a contributing factor to the level of fatigue of CFS/ME.<ref name="Earl2017">[https://doi.org/10.11136/bmjopen-2016-015296 Earl KE, Sakellariou GK, Sinclair M, et al. Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England. BMJ Open. 2017;7(11):e015296. doi:10.1136/bmjopen-2016-015296]</ref>
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