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== Herpesvirus == [[Herpesviruses]] are a family of [[DNA]] [[virus]]es with extremely high prevalence rates. Once a human host is infected, the infection is life-long. While generally, immunocompetent hosts are able to keep the virus in a latent state and remain asymptomatic, several of these viruses can cause symptoms if they reactivate. They can also increase the risk of [[autoimmune disease]] <nowiki/>and [[cancer]].{{Citation needed}} It is unclear whether herpesviruses associated with [[Chronic fatigue syndrome]] play an etiological role or are "bystanders" – opportunistic reactivations under a state of immune dysregulation. In the 1984 I[[1984 Incline Village chronic fatigue syndrome outbreak|ncline village outbreak]], [[Gary Holmes]] <nowiki/>found that patients with what his team hypothesized was [[chronic Epstein-Barr]] had elevated antibody titers to [[Epstein-Barr virus]], [[cytomegalovirus]], [[herpes simplex]] <nowiki/>and [[measles]] <nowiki/>viruses than age-matched controls.<ref>{{Cite journal|url=https://jamanetwork.com/journals/jama/article-abstract/365861 | title = A Cluster of Patients With a Chronic Mononucleosis-like Syndrome Is Epstein-Barr Virus the Cause? | last =Homes | first = Gary P | date = May 1, 1987|journal=Journal of the American Medical Association|volume=257|pages=2297-2302|via=}}</ref> However, the study cohort was defined as patients who had experienced excessive fatigue between January 1 and September 15. A prospective study of 250 primary care patients revealed a higher prevalence of [[chronic fatigue syndrome]] after infectious [[mononucleosis]] (glandular fever) when compared to an ordinary upper respiratory tract infection.<ref>{{Cite journal | last =White | first = P. D. | last2 = Thomas | first2=J.M. | last3 = Amess | first3 = J. | last4 = Crawford | first4= D.H. | last5 = Grover | first5 = S.A. | last6 = Kangro | first6 = H.O. | last7 = Clare | first7 = A.W. | date = Dec 1998 | title = Incidence, risk and prognosis of acute and chronic fatigue syndromes and psychiatric disorders after glandular fever |url =https://www.ncbi.nlm.nih.gov/pubmed/9926075|journal=The British Journal of Psychiatry: The Journal of Mental Science|volume=173|pages=475–481|issn=0007-1250|pmid=9926075}}</ref> Anti-early antigen titers to Epstein-Barr virus were elevated in CFS patients and associated with worse symptoms.<ref>{{Cite journal | last =Schmaling | first = K. B. | last2 = Jones | first2=J.F. | date = Jan 1996 | title = MMPI profiles of patients with chronic fatigue syndrome|url=https://www.ncbi.nlm.nih.gov/pubmed/8730646|journal=Journal of Psychosomatic Research|volume=40|issue=1|pages=67–74|issn=0022-3999|pmid=8730646}}</ref>
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