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Valaciclovir
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==Use in ME/CFS== Some [[ME/CFS]] specialists prescribe valaciclovir to help mitigate the effects of the [[Epstein-Barr virus]] which may be reactivated in ME/CFS. Dr. [[A Martin Lerner]] studied the efficacy of higher doses of Valtrex on ME/CFS and concluded that it increased physical functioning, improved [[heart]] functioning, and decreased [[Epstein-Barr virus]] antibody levels. <ref name=":0">{{Cite web|url=http://www.cfstreatmentguide.com/1/post/2015/04/dr-martin-lerners-treatment-protocol-for-mecfs.html | title = Dr. Martin Lerner's Treatment Protocol for ME/CFS|website=CFS Treatment Guide|language=en|access-date=2020-10-08 | date = | last = | first = | authorlink = |archive-url=https://web.archive.org/web/20190214142932/http://treatmentcenterforcfs.com/documents/MECFSTreatmentResourceGuideforPractitioners.pdf|archive-date=2019|url-status=}}</ref> Valtrex inhibits the replication of HH-1, HH-2, HH-3, HH-4 (Herpes simplex (HSV-1, HSV-2), Herpes Zoster (VZV), Epstein Barr (EBV)) and has seen improvements in 85% of ME/CFS patients. Among adolescents, the outcome was even better with 92% responding. Only one patient experienced nausea and discontinued the antiviral. Improvement occurred over the course of 3-5 months with 85% percent of the patients responding by 3 months, and 92% by 5 months. Symptoms of fatigue, exertion induced malaise, excessive sleep, napping, unrefreshing sleep, headaches, cognitive symptoms, and emotional symptoms all resolved.<ref>Henderson, Theodore A. “Valacyclovir treatment of chronic fatigue in adolescents.” Advances in mind-body medicine vol. 28,1 (2014): 4-14.</ref><ref>[https://www.psychiatryadvisor.com/home/opinion/the-role-of-antiviral-therapy-in-chronic-fatigue-treatment/ The Role of Antiviral Therapy in Chronic Fatigue Treatment], Theodore Henderson, MD, PhD, March 2015 </ref> In Dr Lerner's IIMEC3 presentation his slides discuss using Famciclovir at similar dosages to Valtrex. He states in his slides that Famciclovir, "can be substituted and although there is not the strong evidence that we have for valacyclovir, it likely is equally effective." <ref name=":0" />
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