Vagus nerve stimulation

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Revision as of 14:50, December 15, 2020 by Notjusttired (talk | contribs) (Intranasal section)
Ear with crocodile crips attaching electrodes to the auricular concha part of the ear for vagus nerve stimulation
Transcutaneous Vagus Nerve Stimulation at Auricular Brandh of the Vagus Nerve (in red). Source: Jiao et al (2020).

Vagus nerve stimulation or vagal nerve stimulation or VNS is a medical treatment that involves delivering electrical impulses to the vagus nerve via a device that is either implanted or wearable. This VNS device is referred to informally as a "pacemaker for the brain."[1]

The effects of VNS were first observed in the 1880s that massage and compression of the carotid artery in the neck could suppress seizures, an effect attributable to crude, early form of VNS.[2] Currently, VNS is most frequently used as an adjunctive treatment for certain types of intractable epilepsy[3] and treatment-resistant depression.[3][4]

Transcutaneous Vagus Nerve Stimulation[edit | edit source]

Transcutaneous Vagus Nerve Stimulation (t-VNS or ta-VNS) is a wearable form of vagus nerve stimulation involving attaching electrodes to a part of the ear daily, and this can be done by patients at home.[1]

Intranasal Mechanical Stimulation[edit | edit source]

Intranasal mechanical stimulation of the vagus nerve (e.g., using INMEST) is a non-invasive wearable form of vagus nerve stimulation which has been the subject of a small clinical trial in ME/CFS patients who met the Canadian Consensus Criteria. INMEST resulted in an significant improvement in symptoms in moderate and severe ME but no improvement in fatigue.[5]

Surgical VNS[edit | edit source]

VNS can also be delivered via an implantable device, requiring surgery.[1]

It is possible that paced breathing (e.g., via deep breathing exercise, yoga or aerobic exercise) can also influence brain electrical activity, mediated by VNS arising from the diaphragm.

Uses[edit | edit source]

While still experimental, researchers are trialing with vagus nerve stimulation as an adjunct therapy on a host of mental health, neurological, and inflammatory illnesses, including anxiety,[6] atrial fibrillation,[7] chronic pain,[8] Crohn's disease,[9] fibromyalgia,[10] heart failure,[11] insomniaand sleep problems,[12]migraines,[13] and many other conditions. Kevin J. Tracey, MD and his research group at The Feinstein Institute for Medical Research have shown that vagus nerve stimulation has decreased inflammation in methotrexate-resistant rheumatoid arthritis patients.[14]

Mechanisms[edit | edit source]

The vagus nerve can inhibit cytokine release, via release of the neurotransmitter acetylcholine[15] and thereby prevent tissue injury and death. In research studies, stimulation of the vagus nerve prevents the damaging effects of cytokine release in experimental sepsis, endotoxemia,[16] ischemia/reperfusion injury, hemorrhagic shock, arthritis, and other inflammatory syndromes.[17]

ME/CFS[edit | edit source]

News and articles[edit | edit source]

Notable studies[edit | edit source]

  • 2020, Effect of Transcutaneous Vagus Nerve Stimulation at Auricular Concha for Insomnia: A Randomized Clinical Trial[12] - (Full text)

See also[edit | edit source]

Learn more[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 1.2 "Vagus Nerve Stimulation (VNS)". Epilepsy Foundation. Retrieved February 25, 2020.
  2. Lanska, DJ (February 2002). "J.L. Corning and vagal nerve stimulation for seizures in the 1880s". Neurology.
  3. 3.0 3.1 Pisapia, Jared; Baltuch, Gordon (January 22, 2016), "Vagus nerve stimulation: Introduction and technical aspects", in Hamani, Clement; Holtzheimer, Paul; Lozano, Andres; Mayberg, Helen (eds.), Neuromodulation in Psychiatry, Chicester, UK: Wiley-Blackwell, doi:10.1002/9781118801086.ch17/, ISBN 978-1118801048
  4. "Vagus nerve stimulation - Mayo Clinic". www.mayoclinic.org. Retrieved February 25, 2020.
  5. https://doi.org/10.1101/2020.02.20.958249
  6. Fanselow, Michael S. (June 1, 2013), "Fear and anxiety take a double hit from vagal nerve stimulation", Biological Psychiatry, 73 (11): 1043–1044, doi:10.1016/j.biopsych.2013.03.025, ISSN 1873-2402, PMID 23647735
  7. Stavrakis, Stavros; Humphrey, Mary Beth; Scherlag, Benjamin J.; Hu, Yanqing; Jackman, Warren M.; Nakagawa, Hiroshi; Lockwood, Deborah; Lazzara, Ralph; Po, Sunny S. (March 10, 2015), "Low-level transcutaneous electrical vagus nerve stimulation suppresses atrial fibrillation", Journal of the American College of Cardiology, 65 (9): 867–875, doi:10.1016/j.jacc.2014.12.026, ISSN 1558-3597, PMID 25744003 no-break space character in |title= at position 78 (help)
  8. Chakravarthy, Krishnan; Chaudhry, Hira; Williams, Kayode; Christo, Paul J. (December 2015), "Review of the Uses of Vagal Nerve Stimulation in Chronic Pain Management", Current Pain and Headache Reports, 19 (12): 54, doi:10.1007/s11916-015-0528-6, ISSN 1534-3081, PMID 26493698
  9. Bonaz, B.; Sinniger, V.; Hoffmann, D.; Clarençon, D.; Mathieu, N.; Dantzer, C.; Vercueil, L.; Picq, C.; Trocmé, C.; Faure, P.; Cracowski, J.-L.; Pellissier, S. (June 2016), "Chronic vagus nerve stimulation in Crohn's disease: a 6-month follow-up pilot study", Neurogastroenterology and Motility: The Official Journal of the European Gastrointestinal Motility Society, 28 (6): 948–953, doi:10.1111/nmo.12792, ISSN 1365-2982, PMID 26920654
  10. Lange, Gudrun; Janal, Malvin N.; Maniker, Allen; Fitzgibbons, Jennifer; Fobler, Malusha; Cook, Dane; Natelson, Benjamin H. (September 2011), "Safety and efficacy of vagus nerve stimulation in fibromyalgia: a phase I/II proof of concept trial", Pain Medicine (Malden, Mass.), 12 (9): 1406–1413, doi:10.1111/j.1526-4637.2011.01203.x, ISSN 1526-4637, PMID 21812908
  11. Hauptman, Paul J.; Schwartz, Peter J.; Gold, Michael R.; Borggrefe, Martin; Van Veldhuisen, Dirk J.; Starling, Randall C.; Mann, Douglas L. (June 2012), "Rationale and study design of the increase of vagal tone in heart failure study: INOVATE-HF", American Heart Journal, 163 (6): 954–962.e1, doi:10.1016/j.ahj.2012.03.021, ISSN 1097-6744, PMID 22709747
  12. 12.0 12.1 Jiao, Yue; Guo, Xiao; Luo, Man; Li, Suxia; Liu, Aihua; Zhao, Yufeng; Zhao, Bin; Wang, Dequan; Li, Zaifang (August 7, 2020). "Effect of Transcutaneous Vagus Nerve Stimulation at Auricular Concha for Insomnia: A Randomized Clinical Trial". Evidence-Based Complementary and Alternative Medicine. doi:10.1155/2020/6049891. PMC 7429019. PMID 32831871. Retrieved December 15, 2020.
  13. Silberstein, Stephen D.; Calhoun, Anne H.; Lipton, Richard B.; Grosberg, Brian M.; Cady, Roger K.; Dorlas, Stefanie; Simmons, Kristy A.; Mullin, Chris; Liebler, Eric J.; Goadsby, Peter J.; Saper, Joel R.; EVENT Study Group (August 2, 2016), "Chronic migraine headache prevention with noninvasive vagus nerve stimulation: The EVENT study", Neurology, 87 (5): 529–538, doi:10.1212/WNL.0000000000002918, ISSN 1526-632X, PMID 27412146
  14. "Kevin J. Tracey, MD". feinstein.northwell.edu. Retrieved February 25, 2020. Cite has empty unknown parameter: |dead-url= (help)
  15. Lund, D. D.; Oda, R. P.; Pardini, B. J.; Schmid, P. G. (March 1986), "Vagus nerve stimulation alters regional acetylcholine turnover in rat heart", Circulation Research, 58 (3): 372–377, ISSN 0009-7330, PMID 3719926
  16. Borovikova, Lyudmila V.; Ivanova, Svetlana; Zhang, Minghuang; Yang, Huan; Botchkina, Galina I.; Watkins, Linda R.; Wang, Haichao; Abumrad, Naji; Eaton, John W.; Tracey, Kevin J. (May 25, 2000), "Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin", Nature, 405 (6785): 458–462, doi:10.1038/35013070, ISSN 0028-0836, retrieved December 12, 2016
  17. Tracey, Kevin J. (February 1, 2007), "Physiology and immunology of the cholinergic antiinflammatory pathway", Journal of Clinical Investigation, 117 (2): 289–296, doi:10.1172/JCI30555, ISSN 0021-9738, PMID 17273548, retrieved December 12, 2016
  18. Knapton, Sarah (July 7, 2016), "Electronic implant in 'Spock' nerve could reverse rheumatoid arthritis", The Telegraph, London, retrieved December 12, 2016
  19. Johnson, Cort (January 11, 2016), "Vagus Nerve Stimulation, Fibromyalgia and Chronic Fatigue Syndrome (ME/CFS)", HealthRising, Henderson, NV, retrieved December 12, 2016
  20. Behar, Michael (May 23, 2014), "Can the Nervous System Be Hacked?", The New York Times, retrieved December 12, 2016