Vagus nerve infection hypothesis
The Vagus Nerve Infection Hypothesis (VNIH) proposes that the symptoms of Chronic Fatigue Syndrome are caused by an infection of the vagus nerve.
In 2013, Michael VanElzakker, a postdoctoral researcher at Harvard Medical School, published the hypothesis.[1]
The vagus nerve is responsible for the sickness response, an involuntary response characterized by fatigue, fever, myalgia, depression, and other symptoms that are often observed in patients with CFS.[2]
Theory[edit | edit source]
VanElzakker believes that any infectious agent with an affinity for nerve tissues can cause a vagus nerve infection, including HHV-6, Epstein-Barr virus, Varicella zoster virus, chicken pox, certain kinds of enteroviruses and even Borrelia, the bacterium that causes Lyme disease. He thinks this could explain why no single infective agent has been isolated as the cause of CFS, even though all of these agents have been associated with disease.[3]
Treatment[edit | edit source]
Evidence[edit | edit source]
Notable studies[edit | edit source]
- 2016: Autonomic correlations with MRI are abnormal in the brainstem vasomotor centre in Chronic Fatigue Syndrome[4]
Learn more[edit | edit source]
- 2016: Vagus Nerve Infection Hypothesis and the Driscoll Theory
- 2013, Article about Michael VanElzakker and his theory on the HHV-6 Foundation Website
- Michael VanElzakker quotes Louis Pasteur in reference to the Vagus Nerve Infection Hypothesis: "The germ is nothing; the terrain is everything."
See also[edit | edit source]
References[edit | edit source]
<references>
- ↑ 1.0 1.1 Van ElZakker, MB (September 2013), "Chronic fatigue syndrome from vagus nerve infection: a psychoneuroimmunological hypothesis" (PDF), Medical Hypotheses, 81 (3): 414-423, doi:10.1016/j.mehy.2013.05.034, PMID 23790471
- ↑ http://hhv-6foundation.org/news/cfs-a-herpesvirus-infection-of-the-vagus-nerve
- ↑ 3.0 3.1 Ykelenstam, Yasmina; Van ElZakker, MB (December 8, 2015), "Harvard Neuroscientist Dr. Michael Van ElZakker: Chronic Fatigue Vagus Nerve Link", The Low Histamine Chef (interview)
- ↑ 4.0 4.1 Barnden, LR; Kwiatek, R; Crouch, B; Burnet, R; Del Fante, P (2016), "Autonomic correlations with MRI are abnormal in the brainstem vasomotor centre in Chronic Fatigue Syndrome", NeuroImage: Clinical, 11: 530-537, doi:10.1016/j.nicl.2016.03.017