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Vagus nerve infection hypothesis
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=== [[Glial cell]] inhibitors === Drugs such as [[ibudilast]] (brand names Ketas or Pinatos or in Japan), an anti-inflammatory drug used for over 20 years in Japan, mostly for asthma and post-stroke [[dizziness]].<ref name="Rolan2009" /> Ibudilast can be combined with [[opioid]]s to reduce chronic [[nerve pain]].<ref name="Rolan2009">{{Cite journal | title = Ibudilast: a review of its pharmacology, efficacy and safety in respiratory and neurological disease | date = Dec 2009|url=https://www.researchgate.net/publication/40023191_Ibudilast_A_review_of_its_pharmacology_efficacy_and_safety_in_respiratory_and_neurological_disease|journal=Expert Opinion on Pharmacotherapy|volume=10|issue=17|pages=2897β2904 | last =Rolan | first=P | authorlink = | last2 = Hutchinson | first2 = MR|author-link2 = | last3 = Johnson | first3=KW | authorlink3 = |language=en|doi=10.1517/14656560903426189|pmc=|pmid=|access-date=|issn=1465-6566|quote=|via=}}</ref> Ibudilast is also a phosphodiesterase (PDE) inhibitor, and crosses the [[blood-brain barrier]] and suppresses glial cell activation.
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