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Tubulin polymerization promoting protein
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'''Tubulin Polymerization Promoting Protein''' or '''TPPP''' is a protein-encoding gene that may be associated with [[myalgic encephalomyelitis|ME]]/[[chronic fatigue syndrome|CFS]].<ref name="Hajdarevic2022" /> The TPPP protein is an antibody expressed in the [[brain]].<ref name="Hajdarevic2022" /><ref name="TPPP">{{Cite web|url=https://www.genecards.org/cgi-bin/carddisp.pl?gene=TPPP | title = TPPP Gene {{!}} TPPP Protein {{!}} TPPP Antibody | last = | first = | authorlink = | date = |website=GeneCards|archive-url=|archive-date=|url-status=|access-date=2022-03-29}}</ref> ==Function == ==ME/CFS == The largest genetic study of ME/CFS patients was published by Hajdarevic et al. in 2022; and analysed data from over 2,500 patients from the UK Biobank, Norway and Denmark, reported they "did not find any ME/CFS risk loci displaying genome-wide significance". The study did find that the [[tubulin polymerization promoting protein|Tubulin Polymerization Promoting Protein]] (TPPP) region may be implicated in ME/CFS.<ref name="Hajdarevic2022" /> ==Notable studies == *2022, Genetic association study in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) identifies several potential risk loci<ref name="Hajdarevic2022">{{Cite journal | title = Genetic association study in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) identifies several potential risk loci | date = 2022-05-01|url=https://www.sciencedirect.com/science/article/pii/S0889159122000782|journal=Brain, Behavior, and Immunity|volume=102|issue=|pages=362–369 | last =Hajdarevic | first = Riad | authorlink = Riad Hajdarevic | last2 = Lande | first2 = Asgeir | authorlink2 = Asgeir Lande | last3 = Mehlsen | first3 = Jesper | author-link3 = | last4 = Rydland | first4=Anne | authorlink4 = | last5 = Sosa | first5 = Daisy D. | authorlink5 = | last6 = Strand | first6 = Elin B. | authorlink6 = Elin Strand | last7 = Mella | first7 = Olav | authorlink7 = Olav Mella | last8 = Pociot | first8 = Flemming | last9 = Fluge | first9 = Øystein | authorlink9 = Øystein Fluge | last10 = Lie | first10 = Benedicte A. | last11 = Viken | first11 = Marte K.|language=en|doi=10.1016/j.bbi.2022.03.010|pmc=|pmid=|access-date=|issn=0889-1591|quote=|via=}}</ref> - [https://www.sciencedirect.com/science/article/pii/S0889159122000782 (Full text)] ==See also == *[[Genetics of chronic fatigue syndrome]] *[[Brain]] ==Learn more == *[https://www.genecards.org/cgi-bin/carddisp.pl?gene=TPPP TPPP Gene {{!}} TPPP Protein {{!}} TPPP Antibody] - GeneCards ==References == {{Reflist}} [[Category:Genes]] [[Category:Proteins]] [[Category:Biochemistry and cell biology]]
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