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Trazodone
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'''Trazodone''' is an [[antidepressant]] drug that has also been marketed under the brand names Desyrel, Oleptro, and Trialodine.<ref name=":0">{{Cite web|url=https://medlineplus.gov/druginfo/meds/a681038.html | title = Trazodone: MedlinePlus Drug Information|website=medlineplus.gov|language=en|access-date=2019-01-09}}</ref> It belongs to the [[serotonin modulator]] class of antidepressants.<ref name=":0" /> There is virtually no evidence for the use of Trazodone to treat [[ME/CFS]]. In 2012 [[Solve ME/CFS Initiative]] contracted [[Biovista]] to use drug models to identify existing drugs that may be worth investigating for treatment. The results suggested Trazodone was worth considering.<ref>[http://solvecfs.org/biovista-work-released Solve ME/CFS Initiative - Results of Biovista Work Released]</ref> ==Notable studies== *2008, [https://www.ncbi.nlm.nih.gov/pubmed/?term=19066412 Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome]<ref name="kumar2008" /> *2010, [https://www.ncbi.nlm.nih.gov/pubmed/20831796 Trazodone for the treatment of fibromyalgia: an open-label, 12-week study]<ref name="morillas2010" /> *2011, [https://www.ncbi.nlm.nih.gov/pubmed/21575194 Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study]<ref name="calandre2011" /> ==Media coverage== *[http://www.cortjohnson.org/blog/2016/02/04/low-dose-naltrexone-combo-chronic-fatigue/ Low Dose Naltrexone Drug Combination Proposed for Chronic Fatigue Syndrome (ME/CFS)] == See also == * [[Low dose naltrexone]] ==Learn more== *[https://en.wikipedia.org/wiki/Trazodone Wikipedia - Trazodone] ==References== <references> <ref name="calandre2011">{{Citation| doi = 10.1186/1471-2474-12-95| issn = 1471-2474| volume = 12| pages = 95| last1 = Calandre | first1 = Elena P. | last2 = Morillas-Arques | first2 = Piedad | last3 = Molina-Barea | first3 = RocΓo | last4 = Rodriguez-Lopez | first4 = Carmen M. | last5 = Rico-Villademoros | first5 = Fernando| title = Trazodone plus pregabalin combination in the treatment of fibromyalgia: a two-phase, 24-week, open-label uncontrolled study| journal = BMC musculoskeletal disorders| date = 2011-05-16 | pmid = 21575194| pmc = 3112435}}</ref> <ref name="morillas2010">{{Citation| doi = 10.1186/1471-2474-11-204| issn = 1471-2474| volume = 11| pages = 204| last1 = Morillas-Arques | first1 = Piedad | last2 = Rodriguez-Lopez | first2 = Carmen Ma | last3 = Molina-Barea | first3 = Rocio | last4 = Rico-Villademoros | first4 = Fernando | last5 = Calandre | first5 = Elena P.| title = Trazodone for the treatment of fibromyalgia: an open-label, 12-week study| journal = BMC musculoskeletal disorders| date = 2010-09-10 | pmid = 20831796| pmc = 2945951}}</ref> <ref name="kumar2008">{{Citation| issn = 1734-1140| volume = 60 | issue = 5| pages = 664β672| last1 = Kumar | first1 = Anil | last2 = Garg | first2 = Ruchika | last3 = Kumar | first3 = Puneet| title = Nitric oxide modulation mediates the protective effect of trazodone in a mouse model of chronic fatigue syndrome| journal = Pharmacological reports: PR| date = October 2008 | pmid = 19066412}}</ref> </references> [[Category:Potential treatments]] [[Category:Antidepressants]] [[Category:Sleep aids and hypnotics]]
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