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Transforming growth factor beta
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Transforming growth factor beta (TGF-β ) is a [[cytokine]] secreted by many types of cells including [[macrophage]]s. TGF-β is disturbed in [[Marfan's syndrome]] and [[Loeys–Dietz syndrome]]. It activates [[fibroblast]] proliferation<ref>{{Cite journal | last =Strutz | first = Frank | last2 = Zeisberg | first2 = Michael | last3 = Renziehausen | first3=Anja | last4 = Raschke | first4 = Birgit | last5 = Becker | first5 = Volker | last6 = Van Kooten | first6 = Cees | last7 = Müller | first7 = Gerhard A. | date = 2001-02-01 | title = TGF-β1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)|url=http://www.sciencedirect.com/science/article/pii/S0085253815475076|journal=Kidney International|volume=59|issue=2|pages=579–592|doi=10.1046/j.1523-1755.2001.059002579.x|issn=0085-2538}}</ref> and stimulates fibroblasts to release [[connective tissue growth factor]] (CTGF).<ref>{{Cite journal | last =Grotendorst | first=Gary R. | date = 1997-09-01 | title = Connective tissue growth factor: a mediator of TGF-β action on fibroblasts|url=http://www.sciencedirect.com/science/article/pii/S1359610197000105|journal=Cytokine & Growth Factor Reviews|volume=8|issue=3|pages=171–179|doi=10.1016/S1359-6101(97)00010-5|issn=1359-6101}}</ref> ==Learn more == == References == {{Reflist}} [[Category:Cytokines]]
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