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Talk:Vagus nerve
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The Pulse of Inflammation: Heart Rate Variability, the Cholinergic Anti-Inflammatory Pathway, and Implications for Therapy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527046/ --[[User:JenB|JenB]] ([[User talk:JenB|talk]]) 01:36, 24 April 2018 (PDT) This can use some clarification. It's both pro and anti-inflammatory? How does that homeostasis work? --[[User:JenB|JenB]] ([[User talk:JenB|talk]]) 01:36, 24 April 2018 (PDT) ''For example, when the vagus nerve detects pro-[[inflammatory]] [[cytokines]] such as [[tumor necrosis factor]]-alpha or interleukin 1-beta, chemoreceptors in the afferent vagus nerve send a signal into the [[brainstem]] that triggers both [[glial cell]] activation within the [[central nervous system]] as well as the general [[innate immune response]], sometimes called the [[sickness response]].[4] The efferent vagus nerve is responsible for an anti-inflammatory pathway.<ref /> The vagus nerve speaks directly to the [[immune system]] via the [[neurotransmitter]] [[acetylcholine]].<ref /><ref /><ref /> Vagus is thus important for maintaining [[homeostasis]] and preventing an overreactive immune response that can cause major injury or death.<ref /> For example, [[vagus nerve stimulation]] is being used experimentally as an adjunct treatment for sepsis, which can cause death via a massive cytokine storm (e.g. Wang et al 2016 Int Rev Immunol). ''
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