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Streptococcus
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=== Symptom improvement === A 2015 study found significant symptom and overall sleep quality improvements among ME/CFS patients by treating Streptococcus and microbiota dysbiosis with Erythromycin.<ref name=":3">{{Cite journal | last= Jackson | first = Melinda L. | last2 = Butt | first2 = Henry | last3 = Ball | first3 = Michelle | last4 = Lewis | first4 = Donald P. | last5 = Bruck | first5 = Dorothy | date = Nov 2015 | title = Sleep quality and the treatment of intestinal microbiota imbalance in Chronic Fatigue Syndrome: A pilot study|url=https://pubmed.ncbi.nlm.nih.gov/26779319/|journal=Sleep Science (Sao Paulo, Brazil)|volume=8|issue=3|pages=124β133|doi=10.1016/j.slsci.2015.10.001|issn=1984-0659|pmc=4688574|pmid=26779319|quote= | last6 = | first6 = | authorlink = Melinda Jackson | author-link2 = Henry Butt|access-date= | authorlink3 = Michelle Ball | author-link4 = Donald Lewis | author-link5 = Dorothy Bruck|via=}}</ref> A 2018 study including 44 adult ME/CFS patients ('''all''' with significant ''Streptococcus'' counts) showed improvements in total symptoms, some sleep, and cognitive symptoms following a 4-week Erythromycin + [[Probiotic|probiotic treatment]]. The [[Antibiotics|antibiotic treatment]] was used to target the overgrowth of Streptococcus bacteria found in [[Microbiome|microbiota]] of ME/CFS patients. The idea was based on previous studies linking lactic acidosis and gut dysbiosis with symptoms of ME/CFS. And that d-lactic acid producing bacteria play a large role in both. Results showed antimicrobial and probiotic treatment yielded concurrent reduction in enteric Streptococcus counts and improvement in some neurological symptoms.<ref name=":4">{{Cite journal | last = Wallis | first = Amy | last2 = Ball | first2 = Michelle | last3 = Butt | first3=Henry | last4 = Lewis | first4 = Donald P. | last5 = McKechnie | first5 = Sandra | last6 = Paull | first6 = Phillip | last7 = Jaa-Kwee | first7 = Amber | last8 = Bruck | first8 = Dorothy | date = 2018-02-06 | title = Open-label pilot for treatment targeting gut dysbiosis in myalgic encephalomyelitis/chronic fatigue syndrome: neuropsychological symptoms and sex comparisons|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801817/|journal=Journal of Translational Medicine|volume=16|doi=10.1186/s12967-018-1392-z|issn=1479-5876|pmc=5801817|pmid=29409505}}</ref>
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