Sarah Myhill: Difference between revisions

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
(→‎Book: copy edit)
(reformatted study section; hyperlinks)
Line 2: Line 2:
Doctor '''Sarah Myhill''' is a British doctor running her own specialist M.E. clinic in Knighton, Powys LD7 1SL, Wales, United Kingdom. [http://www.doctormyhill.co.uk/ Her web site] is an extensive resource of articles and information based on her treatment of patients. The website runs to 920 webpages and has had over 6 million individual visits.
Doctor '''Sarah Myhill''' is a British doctor running her own specialist M.E. clinic in Knighton, Powys LD7 1SL, Wales, United Kingdom. [http://www.doctormyhill.co.uk/ Her web site] is an extensive resource of articles and information based on her treatment of patients. The website runs to 920 webpages and has had over 6 million individual visits.


Dr Myhill's view is that the disease is characterised by a cellular metabolic [[mitochondria]]l dysfunction and has published several studies.<ref name="Myhill2013"/><ref name="Booth2012"/><ref name="Myhill2009"/><ref>[http://drmyhill.co.uk/wiki/CFS_-_The_Central_Cause:_Mitochondrial_Failure CFS - The Central Cause: Mitochondrial Failure]</ref> Dr Myhill has treated in excess of 10,000 CFS/ME sufferers over her 30 year career.
Dr Myhill's view is that [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]] is characterized by a cellular metabolic [[mitochondria]]l dysfunction and has published several studies.<ref name="Myhill2013"/><ref name="Booth2012"/><ref name="Myhill2009"/><ref>[http://drmyhill.co.uk/wiki/CFS_-_The_Central_Cause:_Mitochondrial_Failure CFS - The Central Cause: Mitochondrial Failure]</ref> Dr Myhill has treated in excess of 10,000 CFS/ME sufferers over her 30 year career.


Dr Myhill explains her philosophy of medicine [http://www.doctormyhill.co.uk/wiki/About_my_practice here]
Dr Myhill explains her philosophy of medicine [http://www.doctormyhill.co.uk/wiki/About_my_practice here]
Line 13: Line 13:


==Notable studies==
==Notable studies==
*2013, Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) [http://www.ijcem.com/files/IJCEM1207003.pdf (FULL TEXT)]<blockquote>Abstract: "We report on an audit of 138 ME/CFS patients who attended a private practice  and took the ATP Profile biomedical test. The results revealed that all of these patients had measureable mitochondrial dysfunction. A basic treatment regime, based on 1) eating the evolutionary correct stone-age diet, 2) ensuring optimum hours of good quality sleep, 3) taking a standard package of nutritional supplements, and 4) getting the right balance between work and rest, was recommended for all patients. Additions to the basic regime were tailored for each patient according to the results of the ATP Profile and additional nutritional tests and clues from the clinical history. Mitochondrial function is typically impaired in two ways: substrate or co-factor deficiency, and inhibition by chemicals, exogenous or endogenous. For the former, additional nutrients are recommended where there is a deficiency, and for the latter, improvement of anti-oxidant status and selective chelation therapy  or far-infrared saunas are appropriate. We show case histories of nine patients who have taken the ATP Profile on three or four occasions, and a before-and-after treatment summary of the 34 patients who have had at least two ATP Profile tests separated by some months. Finally, we summarize the results for the 30 patients who followed all aspects of the treatment regime and compare them with the 4 patients  who were lax on two or more aspects of the treatment regime. All patients who followed the treatment  regime improved in mitochondrial function by on average a factor of 4."<ref name="Myhill2013"/></blockquote>
*2013, Targeting mitochondrial dysfunction in the treatment of [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]] ([[ME/CFS]])<ref name="Myhill2013"/> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3515971/ (Full Text)]
*2012, Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) [http://www.ijcem.com/files/IJCEM1204005.pdf (FULL TEXT)]<blockquote>Abstract: "The  objectives of this study are to test the hypothesis that the fatigue and accompanying symptoms of Chronic Myalgic Encephalomyelitis/Fatigue Syndrome are in part due to defects in energy provision at the cellular level, and to understand the pathophysiology of the defects so that effective medical  intervention can be implemented. We performed an audit of 138 patients (ages 18-65) diagnosed with ME/CFS and attending a private practice. The patients and 53 normal, healthy controls had the ATP  Profile test carried out on neutrophils from a 3-ml venous blood sample. This test yields 6 numerical  factors that describe the availability of ATP and the efficiency of oxidative phosphorylation in mitochondria. Other biomedical measurements, including the concentration of cell-free DNA in plasma, were made. The results of the audit are compared with the controls and a previous cohort of 61 patients. We find that all patients tested have measureable mitochondrial dysfunction which correlates with the severity of the illness. The patients divide into two main groups differentiated by how cellular metabolism attempts to compensate for the dysfunction. Comparisons with exercise studies  suggest that the dysfunction in neutrophils also occurs in other cells. This is confirmed by the cell-free DNA measurements which indicate levels of tissue damage up to 3.5 times the normal reference  range. The major immediate causes of the dysfunction are lack of essential substrates and partial blocking of the translocator protein sites in mitochondria. The ATP Profile is a valuable diagnostic tool for the clinical management of ME/CFS."<ref name="Booth2012"/></blockquote>
*2012, [[Mitochondria|Mitochondrial]] dysfunction and the pathophysiology of [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome]] ([[ME/CFS]])<ref name="Booth2012"/> [http://www.ijcem.com/files/IJCEM1204005.pdf (Full Text)]
*2009, Chronic fatigue syndrome and mitochondrial dysfunction  [http://www.ijcem.com/files/IJCEM812001.pdf (FULL TEXT)] <blockquote>Abstract: "This study aims to improve the health of patients suffering from chronic fatigue syndrome (CFS) by interventions based on the biochemistry of the illness, specifically the function of mitochondria in producing ATP (adenosine triphosphate), the energy currency for all body functions, and recycling ADP (adenosine diphosphate) to replenish the ATP  supply as needed. Patients attending a private medical practice specializing in CFS were diagnosed using the Centers for Disease Control criteria. In consultation with each patient, an integer on the Bell Ability Scale was assigned, and a blood sample was taken for the “ATP profile” test, designed for CFS and other fatigue conditions. Each test produced 5 numerical factors which describe the availability of ATP in neutrophils, the fraction complexed with magnesium, the efficiency of oxidative phosphorylation, and the transfer efficiencies of ADP into the mitochondria and ATP into the cytosolwhere the energy is used. With the consent of each of 71 patients and 53 normal, healthy controls the 5 factors have been collated and compared with the Bell Ability Scale. The individual numerical factors show that patients have different combinations of biochemical lesions. When the factors are combined, a remarkable correlation is observed between the degree of mitochondrial dysfunction and the severity of illness (P<0.001). Only 1 of the 71 patients overlaps the normal region. The “ATP profile” test is a powerful diagnostic tool and can differentiate patients who have fatigue and other symptoms as a result of energy wastage by stress and psychological factors from those who have insufficient energy due to cellular respiration dysfunction. The individual factors indicate  which remedial actions, in the form of dietary supplements, drugs and detoxification, are most likely to be of benefit, and what further tests should be carried out."<ref name="Myhill2009"/></blockquote>
*2009, [[Chronic fatigue syndrome]] and [[Mitochondria|mitochondrial]] dysfunction<ref name="Myhill2009"/> [http://www.ijcem.com/files/IJCEM812001.pdf (Full Text)]  


==Book==
==Book==
Line 36: Line 36:


==Learn more==
==Learn more==
*2012, [http://www.prohealth.com/library/showarticle.cfm?libid=17086 "Booth, Myhill, McLaren-Howard Comment on ME/CFS Mitochondrial Dysfunction Paper" by Norman E. Booth, Sarah Myhill, John McLaren-Howard for [[ProHealth]]]
*2012, [http://www.prohealth.com/library/showarticle.cfm?libid=17086 "Booth, Myhill, McLaren-Howard Comment on ME/CFS Mitochondrial Dysfunction Paper" by Norman E. Booth, Sarah Myhill, John McLaren-Howard for [[ProHealth]]]
Dr Myhill has a checklist that she recommends all CFS/ME sufferers follow - this can be found at this website address:
Dr Myhill has a checklist that she recommends all CFS/ME sufferers follow - this can be found at this website address:
*[http://www.doctormyhill.co.uk/wiki/CFS_Checklist_-_start_off_and_check_your_treatment_regime_here CFS Checklist - start off and check your treatment regime here]
*[http://www.doctormyhill.co.uk/wiki/CFS_Checklist_-_start_off_and_check_your_treatment_regime_here CFS Checklist - start off and check your treatment regime here]
Line 78: Line 78:
}}
}}
</ref>
</ref>
<ref name="Myhill201004BBC">{{citation
<ref name="Myhill201004BBC">{{citation
| title  = Dr. Myhill on BBC News
| title  = Dr. Myhill on BBC News

Revision as of 20:15, April 23, 2018

Sarahmyhill.jpg

Doctor Sarah Myhill is a British doctor running her own specialist M.E. clinic in Knighton, Powys LD7 1SL, Wales, United Kingdom. Her web site is an extensive resource of articles and information based on her treatment of patients. The website runs to 920 webpages and has had over 6 million individual visits.

Dr Myhill's view is that Myalgic Encephalomyelitis/Chronic Fatigue Syndrome is characterized by a cellular metabolic mitochondrial dysfunction and has published several studies.[1][2][3][4] Dr Myhill has treated in excess of 10,000 CFS/ME sufferers over her 30 year career.

Dr Myhill explains her philosophy of medicine here

Clinical Practice[edit | edit source]

Dr Myhill has an experienced staff supporting her clinical practice. For individuals unable to visit in person staff will coordinate with the individual's primary care provider, will send lab kits for blood draw to be analyzed by Dr Myhill. She produces detailed analysis of blood work, provides recommendations and will discuss cases by telephone. Blood test analysis provides measures of ATP production and mitochondrial efficiency based upon her published research. While other physicians seem to understand her analytical methods, few, if any, are comfortable commenting on their significance. For decades, Dr Myhill has prioritized patient support and treatment results over independent corroboration.

Complaints[edit | edit source]

Dr Myhill has been the subject of complaints to the General Medical Council.[5] A recent Freedom of Information Act request confirmed that Dr Myhill is the most investigated doctor in the history of the GMC. She has been subject to in excess of 30 investigations in the last 15 years. None of the complainants against Dr Myhill were patients. All complaints against her have been dropped and she practises with a full unrestricted medical licence.

Notable studies[edit | edit source]

Book[edit | edit source]

Talks and interviews[edit | edit source]

Contact[edit | edit source]

Learn more[edit | edit source]

Dr Myhill has a checklist that she recommends all CFS/ME sufferers follow - this can be found at this website address:

See also[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 Myhill, S; Booth, NE; McLaren-Howard, J (2013), "Targeting mitochondrial dysfunction in the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) - a clinical audit", International Journal of Clinical Experimental Medicine, 6 (1): 1–15, PMID 23236553
  2. 2.0 2.1 Booth, NE; Myhill, S; McLaren-Howard, J (June 15, 2012), "Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)", International Journal of Clinical Experimental Medicine, 5 (3): 208–220, PMID 22837795
  3. 3.0 3.1 Myhill, S; Booth, NE; McLaren-Howard, J (January 15, 2009), "Chronic fatigue syndrome and mitochondrial dysfunction", International Journal of Clinical Experimental Medicine, 2 (1): 1–16, PMID 19436827
  4. CFS - The Central Cause: Mitochondrial Failure
  5. Dr. Myhill on BBC News (video), April 29, 2010
  6. http://www.investinme.eu/IIMEC2.shtml#agenda