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Rofecoxib
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'''Rofecoxib''' is a [[COX-2 inhibitors|COX-2]] selective nonsteroidal anti-inflammatory drug ([[nonsteroidal anti-inflammatory drug|NSAID]]). It is no longer available, having been voluntarily withdrawn from the market.<ref name="DrugBank">{{Cite web|url=https://www.drugbank.ca/drugs/DB00533| title = Rofecoxib|website=drugbank.ca|access-date=2019-04-27}}</ref> ==Withdrawn from sale== In 2004, rofecoxib was voluntarily withdrawn from sale by manufacturer Merck because of safety concerns about the increased risk of [[stroke]] and [[heart attack]] when high doses are used for the long term.<ref name="DrugBank" /> == Side effects == Using [[Nonsteroidal anti-inflammatory drug|nonsteroidal anti-inflammatory]] precautions is recommended to avoid [[gastrointestinal]] side effects. Hepatic and renal dysfunction may occur, and peripheral edema.<ref name="CanadianConsensusCriteria" /> [[Central nervous system]] side effects include "dizziness, headaches, drowsiness and evidence of hypersensitives." <ref name="CanadianConsensusCriteria" /> More commonly reported ones are: * Gastrointestinal side-effects including bleeding.<ref name="CanadianConsensusCriteria" /> More commonly reported ones in children are: Less commonly reported ones are: ==Evidence == Before being withdrawn from the market Rofecoxib was listed as a suggested drug in the [[Canadian Consensus Criteria]] for [[ME/CFS]], but it was not highlighted as better in any way in comparison to [[celecoxib]] or other NSAIDs.<ref name="CanadianConsensusCriteria">{{Cite journal | last1 = Carruthers | first1 = Bruce M. | authorlink1 = Bruce Carruthers | last2 = Jain | first2 = Anil Kumar | authorlink2 = Anil Kumar Jain | last3 = De Meirleir | first3 = Kenny L. | authorlink3 = Kenny De Meirleir | last4 = Peterson | first4 = Daniel L. | authorlink4 = Daniel Peterson | last5 = Klimas | first5 = Nancy G. | authorlink5 = Nancy Klimas | last6 = Lerner | first6 = A. Martin | authorlink6 = Martin Lerner | last7 = Bested | first7 = Alison C. | authorlink7 = Alison Bested | last8 = Flor-Henry | first8 = Pierre | authorlink8 = Pierre Flor-Henry | last9 = Joshi | first9 = Pradip | authorlink9 = Pradip Joshi | last10 = Powles | first10 = AC Peter | authorlink10 = A C Peter Powles | last11 = Sherkey | first11 = Jeffrey A. | authorlink11 = Jeffrey Sherkey | last12 = van de Sande | first12 = Marjorie I. | authorlink12 = Marjorie van de Sande | title = Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Clinical Working Case Definition, Diagnostic and Treatment Protocols | journal = Journal of Chronic Fatigue Syndrome | volume = 11 | issue = 2 | date = 2003 | url = http://www.investinme.org/Documents/PDFdocuments/CanadianDefinitionME-CFS.pdf#page=10 | pages = 55}}</ref> ===Dose=== A dose of 12.5 to 25 mg daily, if needed, was suggested by the Canadian Consensus Criteria.<ref name="CanadianConsensusCriteria" /> ==Learn more== * [https://www.drugbank.ca/drugs/DB00533 Rofecoxib] - DrugBank == See also == * [[COX-2 inhibitors]] * [[Nonsteroidal anti-inflammatory drug|Nonsteroidal anti-inflammatory]] * [[Celecoxib]] == References == {{Reflist}} [[Category:Analgesics]] [[Category:Anti-inflammatories]] [[Category:Nonsteroidal anti-inflammatory drugs]] <!---No longer in the Potential treatments category since withdrawn from the market. --->
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