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Robert Naviaux
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[[File:Robert Naviaux.png|thumb|Source: gordonmedical.com]] '''Robert K. Naviaux,''' MD, PhD, is a Professor in Residence at the University of California, San Diego, California, US. His work "has focused on the role of mitochondrial DNA replication, copy number regulation, DNA damage, and nucleotide signaling in development, aging, healing and regeneration in mitochondrial mechanisms of disease and development."<ref>{{Cite web|url=http://profiles.ucsd.edu/robert.naviaux | title = Robert Naviaux {{!}} UCSD Profiles|website=profiles.ucsd.edu|language=en|access-date=2018-08-15}}</ref> He was invited to join the [[Open Medicine Foundation]]'s research team in 2016, following a announcement that the [[ME/CFS Severely Ill, Big Data Study]] had a significant result in the area of [[Mitochondrion|mitochondria]].<ref name=":0">{{Cite news | url=https://www.omf.ngo/2016/02/10/welcome-dr-naviaux-to-our-team/ | title = Welcome Dr. Naviaux to our Team {{!}} Open Medicine Foundation | date = 2016-02-10|work=Open Medicine Foundation|access-date=2018-08-15|language=en-US}}</ref> Dr. Naviaux directs the Robert Naviaux Laboratory at University of California, San Diego (UCSD) whose work is "divided into two groups: 1) Mitochondrial Mechanisms of Disease and Development, and 2) Evolutionary Systems Biology and Marine Metagenomics."<ref>{{Cite web|url=http://med.ucsd.edu/divisions/med-genetics/research/Pages/Naviaux-Lab.aspx | title = Naviaux Laboratory Genetics Research at UC San Diego|website=UC San Diego School of Medicine|language=en-US|access-date=2018-08-15}}</ref> He is founder and co-director of the Mitochondrial and Metabolic Disease Center at UCSD, the co-founder and a former president of the Mitochondrial Medicine Society, as well as, a founding associate editor of the journal, ''Mitochondrion''.<ref name=":0" /> Dr. Naviaux "discovered the cause and created the diagnostic test for Alpers syndrome, a mitochondrial disease... [and] is the director of the first FDA-approved clinical trial to study [https://www.drugs.com/cons/suramin-injection.html suramin] [an antiparasitic drug] as a treatment for autism."<ref name=":0" /><ref>{{Cite web|url=https://health.ucsd.edu/news/releases/Pages/2015-06-10-clinical-trial-for-autism-treatment.aspx | title = Clinical Trial Launched to Assess Safety and Efficacy of Autism Drug Treatment | last = LaFee | first = Scott | date = Jun 10, 2015 | website = UC Health - UC San Diego|language=en-US|archive-url=|archive-date=|url-status=|access-date=2018-08-15}}</ref> Currently, Dr. Naviaux is using his mitochondria expertise, especially in metabolomics, to look for a biomarker and potential treatment for [[ME/CFS]].<ref>{{Cite news | url=http://www.healthrising.org/forums/threads/the-mitochondria-man-gets-his-money-and-the-uk-goes-mega-me-cfs-research-moving-forward.4360/ | title = The Mitochondria Man Gets His Money and The UK Goes MEGA: ME/CFS Research Moving Forward | last = | first = | date = May 19, 2016|work=Health Rising's Chronic Fatigue Syndrome (ME/CFS) and Fibromyalgia Forums|access-date=2018-08-15|archive-url=|archive-date=|url-status=|language=en-US|type=Forum Discussion}}</ref> In May 2016, a study was launched, led by Dr. Naviaux and Dr. [[Ronald Davis]], in collaboration with Dr. [[Eric Gordon]], Dr. [[Paul Cheney]], and the Stanford Genome Technology Center in order "to validate earlier findings of a possible diagnostic signature for ME/CFS by measuring metabolites and to evaluate the contribution of genetics to the variation in observed metabolic signatures in this disease." The initial phase, with a total of 90 participants, has been completed and suggests "the mitochondria is in hypometabolism due to a chronic [[Cell danger response hypothesis|cell danger response]] state in ME/CFS patients."<ref>{{Cite news | url=https://www.omf.ngo/expanded-mecfs-metabolomics-study/ | title = Metabolomics and Genetics Study {{!}} Open Medicine Foundation|work=Open Medicine Foundation|access-date=2018-08-15|language=en-US}}</ref> ==Education== *1977-1978 - Undergraduate (Biochemistry), Georg August Universität, Göttingen, Germany *1979 - B.S. (Biological Sciences), University of California, Davis, California *1981 - M.S. (Zoology), Indiana University, Bloomington, Indiana *1986, 1989 - M.D., Ph.D. (Genetics, Virology), Indiana University School of Medicine, Indianapolis, Indiana *1986-1990 - Internship and Residency, Internal Medicine, American Board of Internal Medicine (ABIM), Clinical Investigator Pathway, University of California, Davis *1990-1994 - Postdoctorate (Retrovirology, Gene Therapy), The Salk Institute, La Jolla, California *1994-1997 - Fellowship (Biochemical Genetics, mtDNA Replication), University of California, San Diego Medical Center, San Diego, California ==Notable studies== *2004, [http://www.ncbi.nlm.nih.gov/pubmed/16120397 Developing a systematic approach to the diagnosis and classification of mitochondrial disease] *2008, [http://www.tandfonline.com/doi/pdf/10.4161/cbt.7.8.6741 Mitochondrial control of epigenetics] *2014, Metabolic features of the cell danger response<ref name="Naviaux, 2014">{{Citation | last1 = Naviaux | first1 = Robert K. | authorlink1 = Robert Naviaux | title = Metabolic features of the cell danger response | journal = Mitochondrion | volume = 16 | issue = | page = 7–17 | date = May 2014 | pmid = 23981537 | doi = 10.1016/j.mito.2013.08.006 }}</ref> [http://www.sciencedirect.com/science/article/pii/S1567724913002390 (Full Text)] *Sep 13, 2016, Metabolic features of chronic fatigue syndrome<ref name="Naviaux, 2016">{{Citation | last1 = Naviaux | first1 = Robert K | authorlink1 = Robert Naviaux | last2 = Naviaux | first2 = Jane C. | authorlink2 = | last3 = Li | first3 = Kefeng | author-link3 = | last4 = Bright | first4 = A. Taylor | authorlink4 = | last5 = Alaynick | first5 = William A. | authorlink5 = | last6 = Wang | first6 = Lin | authorlink6 = | last7 = Baxter | first7 = Asha | authorlink7 = | last8 = Nathan | first8 = Neil | authorlink8 = | last9 =Anderson | first9 = Wayne | authorlink9 = | last10 = Gordon | first10 = Eric | authorlink10 = Eric Gordon | title = Metabolic features of chronic fatigue syndrome | journal = PNAS | volume = 113 | issue = 37 | page = | date = Sep 13, 2016 | doi = 10.1073/pnas.1607571113}}</ref>[http://www.pnas.org/content/early/2016/08/24/1607571113.long (Full Text)] ::*Nov 15, 2016, Reply to Vogt et al.: Metabolomics and chronic fatigue syndrome<ref name="Naviaux, Nov152016">{{Citation | last1 = Naviaux | first1 = Robert K | authorlink1 = Robert Naviaux | last2 = Naviaux | first2 = Jane C. | authorlink2 = | last3 = Li | first3 = Kefeng | author-link3 = | last4 = Bright | first4 = A. Taylor | authorlink4 = | last5 = Alaynick | first5 = William A. | authorlink5 = | last6 = Wang | first6 = Lin | authorlink6 = | last7 = Baxter | first7 = Asha | authorlink7 = | last8 = Nathan | first8 = Neil | authorlink8 = | last9 =Anderson | first9 = Wayne | authorlink9 = | last10 = Gordon | first10 = Eric | authorlink10 = Eric Gordon | title = Reply to Vogt et al.: Metabolomics and chronic fatigue syndrome | journal = Proc Natl Acad Sci USA | volume = 113 | issue = 46 | page = E7142–E7143 | date = Nov 15, 2016 | pmid = | doi = 10.1073/pnas.1616261113}}</ref> ::*Feb 7, 2017, Reply to Roerink et al.: Metabolomics of chronic fatigue syndrome<ref name="Naviaux, Feb72017">{{Citation | last1 = Naviaux | first1 = Robert K | authorlink1 = Robert Naviaux | last2 = Gordon | first2 = Eric | authorlink2 = Eric Gordon | title = Reply to Roerink et al.: Metabolomics of chronic fatigue syndrome. | journal = Proc Natl Acad Sci USA | volume = 114 | issue = 6 | page = E911-E912 | date = Feb 7, 2017 | pmid = | doi = 10.1073/pnas.1618984114}}</ref> *2017, A robust, single-injection method for targeted, broad-spectrum plasma metabolomics<ref name="Li, 2017">{{Citation | last1 = Li | first1 = Kefeng | author-link1 = | last2 = Naviaux | first2 = Jane C. | authorlink2 = | last3 = Bright | first3 = A. Taylor | authorlink3 = | last4 = Wang | first4 = Lin | authorlink4 = | last5 = Naviaux | first5 = Robert K | authorlink5 = Robert Naviaux | title = A robust, single-injection method for targeted, broad-spectrum plasma metabolomics| journal = Metabolomics | volume = 13 | issue = 122 | page = | date = 2017 | doi = 10.1007/s11306-017-1264-1}}</ref>[https://link.springer.com/article/10.1007/s11306-017-1264-1 (Full Text)] *2020, Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome<ref name="Schreiner2020">{{Cite journal | last = Schreiner | first=Philipp | author-link = | last2 = Harrer | first2 = Thomas | authorlink2 = Thomas Harrer | last3 = Scheibenbogen | first3 = Carmen | author-link3 = Carmen Scheibenbogen | last4 = Lamer | first4 = Stephanie | authorlink4 = | last5 = Schlosser | first5 = Andreas | authorlink5 = | last6 = Naviaux | first6 = Robert K. | authorlink6 = Robert Naviaux | last7 = Prusty | first7 = Bhupesh K. | authorlink7 = Bhupesh Prusty | date = 2020-04-01 | title = Human Herpesvirus-6 Reactivation, Mitochondrial Fragmentation, and the Coordination of Antiviral and Metabolic Phenotypes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome|url=https://www.immunohorizons.org/content/4/4/201|journal=ImmunoHorizons|language=en|volume=4|issue=4|pages=201–215|doi=10.4049/immunohorizons.2000006|issn=2573-7732|pmc=|pmid=32327453|access-date=|quote=|via=}}</ref> [https://www.immunohorizons.org/content/4/4/201 (Full text)] ==Awards and Honors== *2002, Honored in a non-fiction book entitled, ''Anna’s Friends — Lessons Learned from a Short and Beautiful Life'' *2007, Thomson ESI - Science Citation Index “Fast Moving Front Article” *2007, United Mitochondrial Disease Foundation Mitochondrial Medicine - Best Abstract Award *2008, Hailey’s Wish Foundation - Hailey’s Hero Award, For Outstanding Research and Clinical Care of children with mitochondrial disease ==Talks and interviews== *2011, [https://www.youtube.com/watch?v=1Sq2Os0mtrQ Mitochondria and Autism (Spring 2011) - Robert K. Naviaux, M.D., Ph.D.]<ref>{{Cite web|url=https://www.youtube.com/watch?v=1Sq2Os0mtrQ | title = Mitochondria and Autism (Spring 2011) - Robert K. Naviaux, M.D., Ph.D. | last=Naviaux | first = Robert K. | date = Jan 27, 2013 | website = YouTube|publisher=Saul Colquhoun|archive-url=|archive-date=|url-status=|access-date=}}</ref> *Aug 12, 2017, [[Community Symposium on the Molecular Basis of ME/CFS - 2017]] *''Sep 28, 2017,'' [https://www.youtube.com/watch?v=u028TAyB9S4 Robert Naviaux, MD, PhD | ME/CFS Cell Danger Response, Metabolic Features, Low-energy in Nature]<ref>{{Cite web|url=https://www.youtube.com/watch?v=u028TAyB9S4 | title = Robert Naviaux, MD, PhD {{!}} ME/CFS Cell Danger Response, Metabolic Features, Low-energy in Nature | last = Naviaux | first = Robert | date = Sep 28, 2017 | website = YouTube|publisher=Open Medicine Foundation - OMF|archive-url=|archive-date=|url-status=|access-date=}}</ref> :([https://www.youtube.com/watch?v=snQnfFTx1Do with Spanish subtitles])<ref>{{Cite web|url=https://www.youtube.com/watch?v=snQnfFTx1Do | title = PART 2 ME CFS Symposium at Stanford trimmed | last = Naviaux | first = Robert | date = Aug 13, 2017 | website = YouTube|publisher=Asociación Síndrome Fatiga Crónica-SQM|archive-url=|archive-date=|url-status=|access-date=}}</ref> ==Articles== *2016, [http://www.healthrising.org/blog/2016/05/19/mitochondria-man-gets-money-uk-goes-mega-chronic-fatigue-syndrome-research-moves-forward/ "Mitochondria Man Gets His Money and the UK Goes Mega: Chronic Fatigue Syndrome Research Moving Forward"]<ref>{{Cite news | url=https://www.healthrising.org/blog/2016/05/19/mitochondria-man-gets-money-uk-goes-mega-chronic-fatigue-syndrome-research-moves-forward/ | title = The Mitochondria Man Gets His Money and The UK Goes MEGA: ME/CFS Research Moving Forward - Health Rising | last = Johnson | first =Cort | date = 2016-05-19|work=Health Rising|access-date=2018-08-15|archive-url=|archive-date=|url-status=|language=en-US}}</ref> * 2018, [https://timesofsandiego.com/tech/2018/09/07/ucsd-researcher-possibly-makes-breakthrough-in-treatment-of-chronic-illness/ "UCSD Researcher Suggests Chronic Illness Could Be Breakdown in Normal Healing"]<ref>{{Cite news | url=https://timesofsandiego.com/tech/2018/09/07/ucsd-researcher-possibly-makes-breakthrough-in-treatment-of-chronic-illness/ | title = UCSD Researcher Suggests Chronic Illness Could Be Breakdown in Normal Healing - Times of San Diego | date = 2018-09-07|work=Times of San Diego|access-date=2018-09-13|language=en-US}}</ref> == Online presence == *[http://www.healthrising.org/forums/threads/an-eye-on-the-mitochondria-man-robert-naviaux-and-chronic-fatigue-syndrome-me-cfs.4163/ Health Rising Forum for Robert Naviaux] *[http://www.ncbi.nlm.nih.gov/pubmed/?term=Naviaux%20RK%5Bauth%5D PubMed] *[http://profiles.ucsd.edu/robert.naviaux University of California, San Diego Faculty Website] *[https://www.youtube.com/results?search_query=%22Robert+Naviaux%22 Youtube - Talks on Autism] ==Learn more== *[http://naviauxlab.ucsd.edu Robert Naviaux Laboratory at UC San Diego]<ref>{{Cite web|url=http://naviauxlab.ucsd.edu/ | title = Naviaux Lab|website=naviauxlab.ucsd.edu|language=en-US|access-date=2018-08-15}}</ref> *[http://www.nofone.org/#!significance-of-naviaux-2015-fragile-x/ctef The Significance of Reversing Autism-Like Features in Two Distinct Mouse Models With a Single Drug, Suramin]<ref>{{Cite web|url=http://www.nofone.org/significance-of-naviaux-2015-fragile-x | title = N of One {{!}} Promising Research Update | last = Rodakis | first = John | date = Jan 15, 2015 | website = N of One: Autism Research Foundation|language=en|archive-url=|archive-date=|url-status=|access-date=2018-08-15}}</ref> ==See also== *[[Metabolomics]] *[[Mitochondrion]] *[[Dauer]] *[[Metabolic features of chronic fatigue syndrome]] ==References== {{Reflist}} [[Category:Researchers]] [[Category:US researchers]] [[Category:OMF Scientific Advisory Board members]]
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