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RCCX Genetic Module Theory
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==RCCX Theory== Co-inheritance of the highly mutable genes of the RCCX module (CYP21A2, TNXB, C4) may confer vulnerability to familial clusters of overlapping syndromes of chronic illness (hypermobility, [[autoimmune disease]], [[CFS/ME]], [[Mast cell activation syndrome|MCAS]], POTS, psychiatric illness, etc.). CYP21A2 mutations may be the genetic diathesis of the stress-diathesis model of disease for both psychiatric and medical illness. This pathway predisposes to chronic psychiatric illness via: Low basal and spiking [[cortisol]] in utero and in infancy leading to CAPS ([[CYP21A2 Mutation Associated Neuropsychiatric Spectrum]]), putting the person at risk for developing severe [[PTSD]] brain circuitry (dissociative circuits) and all forms of [[Mental health|psychiatric illness]] due to exaggerated stress response, low basal arousal and resultant harm-avoidance and threat circuits (except schizophrenia which can be co-inherited via C4 mutation). CYP21A2 mutations also predispose to medical illnesses, such as ME/CFS, [[Postural orthostatic tachycardia syndrome|POTS]], [[Mast cell activation syndrome|MCAS]], [[Fibromyalgia|FM]], [[chronic Lyme disease]] and are the final common pathway of stress-induced mitochondrial shutdown in ME/CFS due to overwhelmed 21-hydroxylase triggering inflammatory cascades. Additionally, the genes of the RCCX Module have been found to co-segregate, creating overlapping "rare" genetic syndromes within families and individuals. The RCCX module genes include: *[[CYP21A2]] which codes for a crucial [[enzyme]] involved in the acute stress response (21-hydroxylase), mutations are associated with an exaggerated stress response in the setting of low [[basal cortisol]] and [[congenital adrenal hyperplasia]] *[[TNXB]] which codes for [[tenascin X]], an important matrix protein implicated in hypermobility, and *[[C4]], a gene involved in the complement system and implicated in [[schizophrenia]], CVID ([[common variable immune deficiency]]), [[MS]], [[lupus]] and other autoimmune diseases.
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