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Pyrroloquinoline Quinone
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{{stub}} '''Pyrroloquinoline Quinone''' or '''PQQ''' occurs normally in human tissue and certain plants, and is available as a natural supplement.<ref name="Harris2013" /><ref name="Nicolson2018" /> PQQ is believed to induce [[mitochondrial biogenesis]].<ref name="Nicolson2018" /> ==Potential uses == No established uses, although it has [[antioxidant]], [[anti-inflammatory]] and neuroprotective effects and may help with [[mitochondrion dysfunction]] and help modulate [[metabolism|energy metabolism]].<ref name="Nicolson2018" /> ===Cusack Protocol === The [[Cusack Protocol]], which was devised for [[Ehlers-Danlos syndrome]] involves using eight different supplements, including PQQ.<ref name="website">{{Cite web|url=http://ouredsjourney.weebly.com/what-works.html | title = What Works? | last = Cusack | first = Deborah | authorlink = | date = |website=EDS and Polysaccharides|archive-url=|archive-date=|url-status=|access-date=2020-10-04}}</ref><ref name="slides2016">{{Cite web|url=https://www.facebook.com/media/set/?set=a.1749260648627557.1073741829.1680359948850961&type=3 | title = Cusack Protocol (slides) | last = Ehlers-Danlos Support Wilmington | first = | authorlink = | date = Mar 10, 2016 | website = facebook.com|archive-url=|archive-date=|url-status=|access-date=}}</ref> ==Evidence == <ref name="Harris2013" /> No clinical trials of PQQ have involved [[ME/CFS]] patients.<ref name="Nicolson2018" /> ==Risks and safety == Based on limited studies, PQQ appears to be safe, although this has not been confirmed in patients with ME/CFS.<ref name="Nicolson2018" /> ==Costs and availability == PQQ is available over the counter. ==Notable studies == *2018, Mitochondrial Dysfunction and Chronic Disease: Treatment with Membrane Lipid Replacement and Other Natural Supplements<ref name="Nicolson2018">{{Cite book | last = Nicolson | first = Garth L. | author-link = Garth Nicolson | last2 = Ferreira | first2 = Gonzalo | authorlink2 = | last3 = Settineri | first3 = Robert | authorlink3 = | last4 = Ellithorpe | first4 = Rita R. | authorlink4 = | last5 = Breeding | first5 = Paul | authorlink5 = | last6 = Ash | first6 = Michael E. | authorlink6 = | date = 2018 | editor-last=Oliveira | editor-first = Paulo J.|chapter=Mitochondrial Dysfunction and Chronic Disease: Treatment with Membrane Lipid Replacement and Other Natural Supplements | title = Mitochondrial Biology and Experimental Therapeutics|url=https://doi.org/10.1007/978-3-319-73344-9_22|journal=|language=en|location=Cham|publisher=Springer | pages = 499β522|doi=10.1007/978-3-319-73344-9_22|isbn=978-3-319-73344-9|pmc=|pmid=|access-date=|quote=|via=}}</ref> - [http://immed.org/treatment%20considerations/03.12.2012update/IMM.updates%2023.Sept.2018/Mito%20Dysfunct%20Treatment-Mito%20Biology-Nicolson2018.pdf (Book chapter)] *2013, Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects<ref name="Harris2013">{{Cite journal| date = 2013-12-01 | title = Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects | last = Harris | first = Calliandra B. | last2 =Winyoo | first2 =Chowanadisai | first3 = Darya O. | last3 =Mishchuk | first4 = Mike A. | last4 = Satre | first5 = Carolyn M. | last5 = Slupsky | first6 = Robert B. | last6 = Rucker |url =https://www.sciencedirect.com/science/article/pii/S0955286313001599|journal=The Journal of Nutritional Biochemistry|language=en|volume=24|issue=12|pages=2076β2084|doi=10.1016/j.jnutbio.2013.07.008|issn=0955-2863}}</ref> - [https://doi.org/10.1016/j.jnutbio.2013.07.008 (Full text)]] ==Learn more== *[https://doi.org/10.1016/j.jnutbio.2013.07.008 Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects] - Harris et al. (2013) ==See also== *[[Citric acid cycle]] *[[Mitochondrion#dysfunction|Mitochondria dysfunction]] *[[Cusack Protocol]] ==References == {{Reflist}} [[Category:Supplements]] [[Category:Metabolism]] [[Category:Potential treatments]] [[Category:Anti-inflammatories]] [[Category:Antioxidants]]
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