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Proton pump inhibitor
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{{stub}} '''Proton pump inhibitors''' or '''PPIs''' are a class of drugs that reduce levels of [[stomach acid]].<ref name="drugscom" /> Proton pump inhibitors may be used to treat symptoms of '''Gastroesophageal Reflux''' (GERD). Warning: long term use of PPIs is considered a risk factor for the development of SIBO<ref>{{Cite journal| title = Proton Pump Inhibitor Use and the Risk of Small Intestinal Bacterial Overgrowth: A Meta-analysis | date = 2013|url=https://www.cghjournal.org/article/S1542-3565(12)01511-X/pdf|journal=CLINICAL GASTROENTEROLOGY AND HEPATOLOGY|volume=|issue=11|pages=483β490 | last = LO | first = WAIβKIT | author-link = | last2 = CHAN | first2 = Walter W. | authorlink2 = |doi=|pmc=|pmid=|access-date=|quote=|via=}}</ref><ref>{{Cite journal| title = Meta-analysis: proton pump inhibitors moderately increase the risk of small intestinal bacterial overgrowth | date = Jan 2018|url=https://pubmed.ncbi.nlm.nih.gov/28770351/|journal=Journal of Gastroenterology|volume=53|issue=1|pages=27β36 | last = Su | first = Tingting | last2 = Lai | first2 = Sanchuan | last3 = Lee | first3 = Allen | last4 = He | first4 = Xingkang | last5 = Chen | first5 = Shujie|doi=10.1007/s00535-017-1371-9|pmid=28770351|issn=1435-5922}}</ref> (small intestinal bacterial overgrowth), which has symptoms like fatigue and brain fog that are quite similar to conditions Chronic fatigue syndrome. ==Theory== ==Evidence== ==Clinicians== ==Risks and safety== ==Costs and availability== ==List of proton pump inhibitors== Proton pump inhibitors include: *[[Dexlansoprazole]] e.g., Dexilant, Kapidex *[[Esomeprazole]] e.g., Nexium *[[Pantoprazole]] e.g., Protonix *[[Rabeprazole]] e.g., Aciphex<ref name="drugscom" /> ===Systemic mastocytosis=== Proton pump inhibitors for systematic mastocytosis (which is not the same as [[mast cell activation disorder]]) include: *[[Lansoprazole]] e.g., Prevacid, which is used for *[[Omeprazole]] e.g., Prilosec<ref name="drugscom">{{Cite web|url=https://www.drugs.com/drug-class/proton-pump-inhibitors.html| title = List of Proton Pump Inhibitors + Uses, Side Effects|website=Drugs.com|language=en|access-date=2021-02-16}}</ref><ref name="systemic">{{Cite web|url=https://www.drugs.com/condition/systemic-mastocytosis.html| title = Medications for Systemic Mastocytosis|website=Drugs.com|language=en|access-date=2021-02-18}}</ref> ==See also== *[[Stomach acid]] *[[Mast cell activation syndrome]] ==Learn more== * [https://www.drugs.com/drug-class/proton-pump-inhibitors.html Proton pump inhibitors] - drugs.com * drugbank.ca ==References== {{reflist}} [[Category:Potential treatments]]
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