Post-exertional malaise

Post-exertional malaise (PEM) is a worsening of many ME/CFS symptoms as a result of physical or mental exertion. It is often referred to as "The Marker" by patients, ME/CFS organizatons, and clinicians and researchers that work in the ME/CFS field.

Notable studies

• Post-exertion malaise in chronic fatigue syndrome: symptoms and gene expression

Talks & interviews

• Post-Exertion Malaise: The Intersection of Biology and Behavior - Dr. Dane Cook, Solve ME/CFS, November 2015 youtube

Learn more

• 2013, PEM series (Jennie Spotila)
• Post-exertional malaise cause and effect

See also

• Exercise

post-exertional malaise (PEM) - A notable exacerbation of symptoms brought on by small physical or cognitive exertions. PEM may be referred to as a "crash" or "collapse" and can last for days or weeks. Symptoms can include cognitive impairments, muscle pain, trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, and others.

post-exertional malaise (PEM) - A notable exacerbation of symptoms brought on by small physical or cognitive exertions. PEM may be referred to as a "crash" or "collapse" and can last for days or weeks. Symptoms can include cognitive impairments, muscle pain, trouble remaining upright (orthostatic intolerance), sleep abnormalities, and gastro-intestinal impairments, and others.