Post-exertional malaise: Difference between revisions

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'''Post-exertional malaise''' (PEM) is a worsening of many [[ME/CFS]] symptoms as a result of physical or mental exertion.  It is often referred to as "the marker" by patients, ME/CFS organizatons, and clinicians and researchers that work in the ME/CFS field.<ref name="JohnsonCsymptoms"/><ref name="FightFatiguePEM"/>
'''Post-exertional malaise''' (PEM) is a worsening of many [[ME/CFS]] symptoms as a result of physical or mental exertion.  Patients, ME/CFS organizatons, clinicians and researchers that work in the ME/CFS field often referred to it as "the marker," i.e., the main symptom that differentiates [[ME]] and [[CFS]] from other fatiguing illnesses. PEM can last for days to weeks after the exertion.<ref name="JohnsonCsymptoms" /><ref name="FightFatiguePEM" />
 
Worsening symptoms include [[Chronic fatigue (symptom)|chronic fatigue]], flu-like symptoms, brain fog ([[cognitive dysfunction]]), [[unrefreshing sleep]], chronic pain, [[orthostatic intolerance]], [[neurally mediated hypotension]], [[POTS]] and more. "As with the severity, the exertion needed to trigger PEM theories case-by-case. For some, it might kick in after a little bit of exercise on top of a day's regular activities. For others, is incredible as it may seem, it can just take a trip to the mailbox, a shower, or sitting upright for an hour."  <ref>[https://www.verywell.com/what-is-post-exertional-malaise-716023 What Is Post-exertional Malaise - Very Well - Adrienne Dellwo]</ref><ref>[https://www.verywell.com/post-exertional-malaise-715670 Post Exertional Malaise - Very Well - Adrienne Dellwo]</ref><ref>[http://www.webmd.com/chronic-fatigue-syndrome/chronic-fatigue-syndrome-symptoms Chronic Fatigue Syndrome - Web MD]</ref><ref>[http://solvecfs.org/wp-content/uploads/2013/10/pem-series.pdf PEM Series - Solve ME/CFS - Jenny Spotila]</ref> Onset of PEM can be delayed 24-72 hours.<ref>[http://www.whathealth.com/awareness/event/internationalcfsmeawarenessday.html What Health - International CFS/ME Awareness Day 2017 - CFIDS Association of America]</ref>
 
A 2016 DePaul University study focused on deciphering if post-exertional malaise was a generalized, full-body fatigue and/or a muscle-specific fatigue. The results suggested that PEM is composed of two empirically different experiences, one for generalized fatigue and one for muscle-specific fatigue.<ref name="McManimen, 2016" />
 
==2015 Institute of Medicine report==
[[File:2015 IOM report PEM chart.png|right|frame|PEM chart from the 2015 Institute of Medicine report]]
 
This landmark report published in 2015 by the [[United States]] [[Institute of Medicine report]], which assessed all the evidence available, concluded:
 
<blockquote>"There is sufficient evidence that PEM is a primary feature that helps distinguish ME/CFS from other conditions"</blockquote>
 
Pages 84-86 of the report describe the evidence for post-exertional malaise in ME/CFS patients.<ref>[http://www.nap.edu/read/19012/chapter/6?term=exercise#84 Institute of Medicine report pages 84-86, search term exercise]</ref>
 
==Prevalence==
 
==Symptom recognition==
===Required===
 
*In the [[International Consensus Criteria]], postexertional neuroimmune exhaustion is required for a diagnosis of ME.
*In diagnosing [[Systemic Exertion Intolerance Disease]] (SEID).
 
===Optional===
 
*In the [[Fukuda criteria]], the symptom of post-exertional malaise can be used to help form a diagnosis.<ref>[http://www.cfids-me.org/cdcdefine.html The CDC (Fukuda 1994) Definition for Chronic Fatigue Syndrome]</ref> Unusually, it is not a required symptom for diagnosis.
*In the [[Canadian Consensus Criteria]] PEM is an option with an and/or with fatigue although most researchers require PEM.
*In the [[Holmes criteria]], prolonged (24 hours or greater) generalized fatigue after levels of exercise that would have been easily tolerated in the patient's premorbid state is an optional criteria for diagnosis, under the section ''Minor Symptom Criteria''.<ref>[http://www.cfids-me.org/holmes1988.html The 1988 Holmes Definition for CFS]</ref>


==Notable studies==
==Notable studies==
*2013, [http://www.tandfonline.com/doi/abs/10.1080/21641846.2013.838444 Post-exertion malaise in chronic fatigue syndrome: symptoms and gene expression], ''Meyer et al'', 2013<ref name="MeyerJ2013"/>
*2018, Comparing Post-Exertional Symptoms Following Serial Exercise Tests<ref>Lariel J. Mateo, University of the Pacific, Poster at 2018 Pacific Undergraduate Research and Creativity Conference (PURCC)</ref> [https://scholarlycommons.pacific.edu/purcc/2018/events/87/ (Abstract)]
*2015, [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761639/#!po=2.51799 Myalgic Encephalomyelitis: Symptoms and Biomarkers], ''Jason et al'', 2015<ref name="JasonL2015bio"/>
*2016, Deconstructing post-exertional malaise: An exploratory factor analysis<ref name="McManimen, 2016" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325824/ (Full Text)]
*2015, [http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0145453 Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)], ''Shukla et al'', 2015<ref name="ShuklaS2015"/>
*2015, [[Myalgic Encephalomyelitis]]: Symptoms and [[Biomarker]]s<ref name="JasonL2015bio" /> [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761639/#!po=2.51799 (Full Text)]
*2015, Changes in Gut and Plasma [[Microbiome]] following [[Exercise]] Challenge in [[ME/CFS|Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)]]<ref name="ShuklaS2015" /> [http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0145453 (Full Text)]
*2013, Post-exertion malaise in [[chronic fatigue syndrome]]: symptoms and gene expression<ref name="MeyerJ2013" /> [[http://www.tandfonline.com/doi/abs/10.1080/21641846.2013.838444 (Abstract)]
*1999, Demonstration of delayed recovery from fatiguing [[exercise]] in [[chronic fatigue syndrome]] [https://www.ncbi.nlm.nih.gov/pubmed/10209352 (Abstract)]


[[File:2010 VanNess Post exertional worsening of symptoms chart.png]]
[[File:2010 VanNess Post exertional worsening of symptoms chart.png|right|frame|Post-exertional worsening of symptoms,<ref name="VanNess2010" />]]


==Notable articles==
==Notable articles==
*[http://me-cfs.se/blogg/suggestion-to-replace-pem-by-par/ Suggestion to replace PEM (Post Exertional Malaise) with PAR (Post Activity Relapse)], ''ME Blogg'', 2015<ref name="MEBlogg2015"/>
 
*Nov 4, 2016 [http://www.medscape.com/viewarticle/871482#vp_1 Postexertion 'Crash,' not Fatigue per se, Marks Syndrome], MedScape By: Miriam Tucker
 
*Dec 30, 2015 [http://me-cfs.se/blogg/suggestion-to-replace-pem-by-par/ Suggestion to replace PEM (Post Exertional Malaise) with PAR (Post Activity Relapse)], ''ME Blogg'', 2015<ref name="MEBlogg2015" />


==Talks & interviews==
==Talks & interviews==
*2016, [https://www.youtube.com/watch?v=ux93w7yGQ5g&feature=youtu.be Inducing Post-Exertional Malaise in ME/CFS: A Look at the Research Evidence] ([[Peter Rowe]])
*2016, [https://www.youtube.com/watch?v=ux93w7yGQ5g&feature=youtu.be Inducing Post-Exertional Malaise in ME/CFS: A Look at the Research Evidence] ([[Peter Rowe]])
*2015, [https://www.youtube.com/watch?v=vfmrPd4-rIE Post-Exertion Malaise: The Intersection of Biology and Behavior], ''[[Dane Cook]], [[Solve ME/CFS]]''<ref name="CookD20151119v"/>
*2015, [https://www.youtube.com/watch?v=vfmrPd4-rIE Post-Exertion Malaise: The Intersection of Biology and Behavior], ''[[Dane Cook]], [[Solve ME/CFS]]''<ref name="CookD20151119v" />
*2015, [https://www.youtube.com/watch?v=F1PP21TmUPs 72. Gene-expression and exercise / Gen-expressie en inspanning – dr. Lucinda Bateman] ([[Lucinda Bateman]], [[Science for Patients]])
*2013, [https://www.youtube.com/watch?v=zZ8aPYihkpQ CFS gene expression after exercise (part 1)] ([[Lucinda Bateman]])
*2012, [https://www.youtube.com/watch?v=B20H1u1LjCE&feature=youtu.be Top 10 Things You Should Know About Post-Exertional Relapse]  ([[Staci Stevens]])
 
==Possible causes==
Dysfunction of the ATP ADP cycle.  Dr. Sarah Myhill has developed a test to assess ATP profiles.  www.healthrising.org/forums/resources/hips-overview-of-dr-myhills-atp-work-in-chronic-fatigue-syndrome-me-cfs.390/
 
==Potential treatments==


==Learn more==
==Learn more==
*[http://solvecfs.org/wp-content/uploads/2013/10/pem-series.pdf Post-Exertional Malaise in Chronic Fatigue Syndrome], ''[[Jennie Spotila]], [[Solve ME/CFS]]'', 2010<ref name="SpotilaJ2010"/>
 
*[http://solvecfs.org/post-exertional-malaise-cause-and-effect/ Post-Exertional Malaise: Cause and Effect], ''[[Jennie Spotila]], [[Solve ME/CFS]]'', 2012<ref name="SpotilaJ20120523"/>
*[http://www.whathealth.com/awareness/event/internationalcfsmeawarenessday.html International CFS/ME Awareness Day 2017 - What Health] (PEM Definition Included) [[CFIDS Association of America]]
*[http://chronicfatigue.about.com/od/cfsglossary/g/malaise.htm Definition of Post-Exertional Malaise], ''About Health'', 2015<ref name="AboutHealthPEM"/>
*[http://solvecfs.org/wp-content/uploads/2013/10/pem-series.pdf Post-Exertional Malaise in Chronic Fatigue Syndrome], ''[[Jennie Spotila]], [[Solve ME/CFS]]'', 2010<ref name="SpotilaJ2010" />
*[http://solvecfs.org/post-exertional-malaise-cause-and-effect/ Post-Exertional Malaise: Cause and Effect], ''[[Jennie Spotila]], [[Solve ME/CFS]]'', 2012<ref name="SpotilaJ20120523" />
*[http://chronicfatigue.about.com/od/cfsglossary/g/malaise.htm Definition of Post-Exertional Malaise], ''About Health'', 2015<ref name="AboutHealthPEM" />
*[https://www.youtube.com/watch?v=ckT9BbSH0Lo Post-Exertional Malaise] Video, ''[[ME/CFS Ghost]]'', 2016<ref>[https://www.youtube.com/watch?v=ckT9BbSH0Lo Post-Exertional Malaise - The ME/CFS Ghost]</ref>
*[https://www.youtube.com/watch?v=ckT9BbSH0Lo Post-Exertional Malaise] Video, ''[[ME/CFS Ghost]]'', 2016<ref>[https://www.youtube.com/watch?v=ckT9BbSH0Lo Post-Exertional Malaise - The ME/CFS Ghost]</ref>
*2016, [http://www.healthrising.org/blog/2016/07/04/exercise-intolerance-fibromyalgia-chronic-fatigue-pots-explained/ The Exercise Intolerance in POTS, ME/CFS and Fibromyalgia Explained?]


==See also==
==See also==
*[[Exercise]]
*[[Exercise]]


== References ==
== References ==
<references>
<references>
<ref name="AboutHealthPEM">{{citation
<ref name="AboutHealthPEM">{{citation
| author  = About Health
| author  = About Health
Line 33: Line 78:
| url    = http://chronicfatigue.about.com/od/cfsglossary/g/malaise.htm
| url    = http://chronicfatigue.about.com/od/cfsglossary/g/malaise.htm
}}</ref>
}}</ref>
<ref name="CookD20151119v">{{citation
<ref name="CookD20151119v">{{citation
| last1  = Cook              | first1 = DB                  | authorlink1 = Dane Cook
| last1  = Cook              | first1 = DB                  | authorlink1 = Dane Cook
Line 42: Line 86:
| url    = https://www.youtube.com/watch?v=vfmrPd4-rIE
| url    = https://www.youtube.com/watch?v=vfmrPd4-rIE
}}</ref>
}}</ref>
<ref name="FightFatiguePEM">{{citation
<ref name="FightFatiguePEM">{{citation
| author  = Fighting Fatigue
| author  = Fighting Fatigue
| title  = Post-Exertional Malaise – A Hallmark Symptom of ME/CFS
| title  = Post-Exertional Malaise – A Hallmark Symptom of ME/CFS
| access-date = Mar 2016
| access-date = 29 March 2016
| url    = http://www.fightingfatigue.org/post-exertional-malaise-a-hallmark-symptom-of-mecfs/
| url    = http://www.fightingfatigue.org/post-exertional-malaise-a-hallmark-symptom-of-mecfs/
}}</ref>
}}</ref>
<ref name="JasonL2015bio">{{Citation
<ref name="JasonL2015bio">{{Citation
| last1  = Jason            | first1 = LA                  | authorlink1 = Leonard Jason
| last1  = Jason            | first1 = LA                  | authorlink1 = Leonard Jason
| last2  = Zinn              | first2 = ML                  | authorlink2 = Marcie Zinn
| last2  = Zinn              | first2 = ML                  | authorlink2 = Marcie Zinn
| last3  = Zinn              | first3 = MA                  | authorlink3 = Mark Zinn
| last3  = Zinn              | first3 = MA                  | authorlink3 = Mark Zinn
| display-authors = 3
| display-authors =
| title  = Myalgic Encephalomyelitis: Symptoms and Biomarkers
| title  = Myalgic Encephalomyelitis: Symptoms and Biomarkers
| journal = Current Neuropharmacology    | volume = 13(5)    | page = 701-734
| journal = Current Neuropharmacology    | volume = 13(5)    | page = 701-734
Line 61: Line 103:
| url    = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761639/#!po=2.51799
| url    = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761639/#!po=2.51799
}}</ref>
}}</ref>
<ref name="JohnsonCsymptoms">{{citation
<ref name="JohnsonCsymptoms">{{citation
| last1  = Johnson          | first1 = C                | authorlink1 = Cort Johnson
| last1  = Johnson          | first1 = C                | authorlink1 = Cort Johnson
| title  = Health Rising: ME/CFS Symptoms
| title  = Health Rising: ME/CFS Symptoms
| access-date = Mar 2016
| access-date = 29 March 2016
| url    = http://www.cortjohnson.org/about-chronic-fatigue-syndrome-mecfs/symptoms/  
| url    = http://www.cortjohnson.org/about-chronic-fatigue-syndrome-mecfs/symptoms/  
}}</ref>
}}</ref>
 
<ref name="McManimen, 2016">{{Citation
| last1  = McManimen                  | first1 = SL              | authorlink1 =
| last2  = Sunnquist                  | first2 = ML              | authorlink2 = Madison Sunnquist
| last3  = Jason                      | first3 = LA              | authorlink3 = Leonard Jason
| title  = Deconstructing post-exertional malaise: An exploratory factor analysis.
| journal = Journal of Health Psychology    | volume =    | issue =    | page =
| date    = 2016
| pmid    = 27557649
| doi    = 10.1177/1359105316664139
}}
</ref>
<ref name="MEBlogg2015">{{citation
<ref name="MEBlogg2015">{{citation
| author  = ME Blogg
| author  = ME Blogg
Line 75: Line 126:
| url    = http://me-cfs.se/blogg/suggestion-to-replace-pem-by-par/  
| url    = http://me-cfs.se/blogg/suggestion-to-replace-pem-by-par/  
}}</ref>
}}</ref>
<ref name="MeyerJ2013">{{citation
<ref name="MeyerJ2013">{{citation
| last1  = Meyer            | first1 = JD                  | authorlink1 = Jacob D Meyer  
| last1  = Meyer            | first1 = JD                  | authorlink1 = Jacob Meyer  
| last2  = Alan              | first2 = AR                  | authorlink2 = Alan R Light
| last2  = Light            | first2 = AR                  | authorlink2 = Alan Light
| last3  = Shukla            | first3 = SK                  | authorlink3 = Sanjay K Shukla
| last3  = Shukla            | first3 = SK                  | authorlink3 = Sanjay Shukla
| last4  = Clevidence        | first4 = D                  | authorlink4 = Derek Clevidence
| last4  = Clevidence        | first4 = D                  | authorlink4 = Derek Clevidence
| last5  = Yale              | first5 = S                  | authorlink5 = Steven Yale
| last5  = Yale              | first5 = S                  | authorlink5 = Steven Yale
| last6  = Stegner          | first6 = AJ                  | authorlink6 = Aaron J Stegner
| last6  = Stegner          | first6 = AJ                  | authorlink6 = Aaron Stegner
| last7  = Cook              | first7 = DB                  | authorlink7 = Dane Cook
| last7  = Cook              | first7 = DB                  | authorlink7 = Dane Cook
| display-authors = 7
| display-authors =
| title  = Post-exertion malaise in chronic fatigue syndrome: symptoms and gene expression
| title  = Post-exertion malaise in chronic fatigue syndrome: symptoms and gene expression
| journal = Fatigue: Biomedicine, Health & Behavior | volume = 1 | issue = 4 | page = 190-209
| journal = Fatigue: Biomedicine, Health & Behavior | volume = 1 | issue = 4 | page = 190-209
Line 91: Line 141:
| url    = http://www.tandfonline.com/doi/abs/10.1080/21641846.2013.838444  
| url    = http://www.tandfonline.com/doi/abs/10.1080/21641846.2013.838444  
}}</ref>
}}</ref>
<ref name="ShuklaS2015">{{Citation
<ref name="ShuklaS2015">{{Citation
| last1  = Shukla            | first1 = SK                  | authorlink1 = Sanjay K Shukla
| last1  = Shukla            | first1 = SK                  | authorlink1 = Sanjay Shukla
| last2  = Cook              | first2 = D                  | authorlink2 = Dane Cook
| last2  = Cook              | first2 = D                  | authorlink2 = Dane Cook
| last3  = Meyer            | first3 = JD                  | authorlink3 = Jacob D Meyer  
| last3  = Meyer            | first3 = JD                  | authorlink3 = Jacob Meyer  
| last4  = Vernon            | first4 = SD                  | authorlink4 = Suzanne D Vernon
| last4  = Vernon            | first4 = SD                  | authorlink4 = Suzanne Vernon
| last5  = Lee              | first5 = T                  | authorlink5 = Thao Lee
| last5  = Lee              | first5 = T                  | authorlink5 = Thao Lee
| last6  = Clevidence        | first6 = D                  | authorlink6 = Derek Clevidence
| last6  = Clevidence        | first6 = D                  | authorlink6 = Derek Clevidence
| last7  = Robertson        | first7 = CE                  | authorlink7 = Charles E Robertson
| last7  = Robertson        | first7 = CE                  | authorlink7 = Charles Robertson
| last8  = Schrodi          | first8 = SJ                  | authorlink8 = Steven J Schrodi
| last8  = Schrodi          | first8 = SJ                  | authorlink8 = Steven Schrodi
| last9  = Yale              | first9 = S                  | authorlink9 = Steven Yale
| last9  = Yale              | first9 = S                  | authorlink9 = Steven Yale
| last10  = Frank            | first10= DN                  | authorlink10= Daniel N Frank
| last10  = Frank            | first10= DN                  | authorlink10= Daniel Frank
| display-authors = 3
| display-authors = 3
| title  = Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
| title  = Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Line 111: Line 160:
| url    = http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0145453
| url    = http://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0145453
}}</ref>
}}</ref>
<ref name="SpotilaJ2010">{{citation
<ref name="SpotilaJ2010">{{citation
| last1  = Spotila          | first1 = JM                  | authorlink1 = Jennie Spotila
| last1  = Spotila          | first1 = JM                  | authorlink1 = Jennie Spotila
Line 119: Line 167:
| url    = http://solvecfs.org/wp-content/uploads/2013/10/pem-series.pdf
| url    = http://solvecfs.org/wp-content/uploads/2013/10/pem-series.pdf
}}</ref>
}}</ref>
<ref name="SpotilaJ20120523">{{citation
<ref name="SpotilaJ20120523">{{citation
| last1  = Spotila          | first1 = JM                  | authorlink1 = Jennie Spotila
| last1  = Spotila          | first1 = JM                  | authorlink1 = Jennie Spotila
Line 127: Line 174:
| url    = http://solvecfs.org/post-exertional-malaise-cause-and-effect/
| url    = http://solvecfs.org/post-exertional-malaise-cause-and-effect/
}}</ref>
}}</ref>
 
<ref name="VanNess2010">{{Citation
 
| last1  = VanNess                | first1 = M                  | authorlink1 = Mark VanNess
 
| last2  = Stevens                | first2 = S                  | authorlink2 = Staci Stevens
| last3  = Bateman                | first3 = L                  | authorlink3 = Lucinda Bateman
| last4  = Stiles                | first4 = TL                  | authorlink4 = TL Stiles
| last5  = Snell                  | first5 = CR                  | authorlink5 = Christopher Snell
| display-authors =
| title  = Postexertional malaise in women with chronic fatigue syndrome
| journal = Journal of Women's Health    | volume =    | issue =    | page =
| date    = February 2010
| pmid    = 20095909
| doi    = 10.1089/jwh.2009.1507
}}
</ref>
</references>


[[Category:Signs and symptoms]]
[[Category:Signs and symptoms]]

Revision as of 02:52, June 15, 2018

Post-exertional malaise (PEM) is a worsening of many ME/CFS symptoms as a result of physical or mental exertion. Patients, ME/CFS organizatons, clinicians and researchers that work in the ME/CFS field often referred to it as "the marker," i.e., the main symptom that differentiates ME and CFS from other fatiguing illnesses. PEM can last for days to weeks after the exertion.[1][2]

Worsening symptoms include chronic fatigue, flu-like symptoms, brain fog (cognitive dysfunction), unrefreshing sleep, chronic pain, orthostatic intolerance, neurally mediated hypotension, POTS and more. "As with the severity, the exertion needed to trigger PEM theories case-by-case. For some, it might kick in after a little bit of exercise on top of a day's regular activities. For others, is incredible as it may seem, it can just take a trip to the mailbox, a shower, or sitting upright for an hour." [3][4][5][6] Onset of PEM can be delayed 24-72 hours.[7]

A 2016 DePaul University study focused on deciphering if post-exertional malaise was a generalized, full-body fatigue and/or a muscle-specific fatigue. The results suggested that PEM is composed of two empirically different experiences, one for generalized fatigue and one for muscle-specific fatigue.[8]

2015 Institute of Medicine report[edit | edit source]

PEM chart from the 2015 Institute of Medicine report

This landmark report published in 2015 by the United States Institute of Medicine report, which assessed all the evidence available, concluded:

"There is sufficient evidence that PEM is a primary feature that helps distinguish ME/CFS from other conditions"

Pages 84-86 of the report describe the evidence for post-exertional malaise in ME/CFS patients.[9]

Prevalence[edit | edit source]

Symptom recognition[edit | edit source]

Required[edit | edit source]

Optional[edit | edit source]

  • In the Fukuda criteria, the symptom of post-exertional malaise can be used to help form a diagnosis.[10] Unusually, it is not a required symptom for diagnosis.
  • In the Canadian Consensus Criteria PEM is an option with an and/or with fatigue although most researchers require PEM.
  • In the Holmes criteria, prolonged (24 hours or greater) generalized fatigue after levels of exercise that would have been easily tolerated in the patient's premorbid state is an optional criteria for diagnosis, under the section Minor Symptom Criteria.[11]

Notable studies[edit | edit source]

Post-exertional worsening of symptoms,[16]

Notable articles[edit | edit source]

Talks & interviews[edit | edit source]

Possible causes[edit | edit source]

Dysfunction of the ATP ADP cycle. Dr. Sarah Myhill has developed a test to assess ATP profiles. www.healthrising.org/forums/resources/hips-overview-of-dr-myhills-atp-work-in-chronic-fatigue-syndrome-me-cfs.390/

Potential treatments[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

  1. Johnson, C, Health Rising: ME/CFS Symptoms, retrieved March 29, 2016
  2. Fighting Fatigue, Post-Exertional Malaise – A Hallmark Symptom of ME/CFS, retrieved March 29, 2016
  3. What Is Post-exertional Malaise - Very Well - Adrienne Dellwo
  4. Post Exertional Malaise - Very Well - Adrienne Dellwo
  5. Chronic Fatigue Syndrome - Web MD
  6. PEM Series - Solve ME/CFS - Jenny Spotila
  7. What Health - International CFS/ME Awareness Day 2017 - CFIDS Association of America
  8. 8.0 8.1 McManimen, SL; Sunnquist, ML; Jason, LA (2016), "Deconstructing post-exertional malaise: An exploratory factor analysis.", Journal of Health Psychology, doi:10.1177/1359105316664139, PMID 27557649
  9. Institute of Medicine report pages 84-86, search term exercise
  10. The CDC (Fukuda 1994) Definition for Chronic Fatigue Syndrome
  11. The 1988 Holmes Definition for CFS
  12. Lariel J. Mateo, University of the Pacific, Poster at 2018 Pacific Undergraduate Research and Creativity Conference (PURCC)
  13. Jason, LA; Zinn, ML; Zinn, MA (September 2015), "Myalgic Encephalomyelitis: Symptoms and Biomarkers", Current Neuropharmacology, 13(5): 701-734, doi:10.2174/1570159X13666150928105725
  14. Shukla, SK; Cook, D; Meyer, JD; et al. (December 18, 2015), "Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)", Plos One, 10(12), doi:10.1371/journal.pone.0145453
  15. Meyer, JD; Light, AR; Shukla, SK; Clevidence, D; Yale, S; Stegner, AJ; Cook, DB (October 2, 2013), "Post-exertion malaise in chronic fatigue syndrome: symptoms and gene expression", Fatigue: Biomedicine, Health & Behavior, 1 (4): 190-209, doi:10.1080/21641846.2013.838444
  16. VanNess, M; Stevens, S; Bateman, L; Stiles, TL; Snell, CR (February 2010), "Postexertional malaise in women with chronic fatigue syndrome", Journal of Women's Health, doi:10.1089/jwh.2009.1507, PMID 20095909
  17. ME Blogg (December 30, 2015), Suggestion to replace PEM by PAR
  18. Cook, DB (November 19, 2015), "Deciphering Post Exertion Malaise: The Intersection of Biology and Behavior", Solve ME/CFS (video)
  19. Spotila, JM (2010), "Post-Exertional Malaise in Chronic Fatigue Syndrome" (PDF), Solve ME/CFS
  20. Spotila, JM (May 23, 2012), "Post-Exertional Malaise: Cause and Effect", Solve ME/CFS
  21. About Health (October 8, 2015), Definition of Post-Exertional Malaise
  22. Post-Exertional Malaise - The ME/CFS Ghost