Post-exertional malaise: Difference between revisions
From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
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| last1 = Van Oosterwijck | first1 = J | authorlink1 = J Van Oosterwijck | |||
| last2 = Nijs | first2 = J | authorlink2 = J Nijs | |||
| last3 = Meeus | first3 = M | authorlink3 = M Meeus | |||
| last4 = Lefever | first4 = I | authorlink4 = I Lefever | |||
| last5 = Huybrechts | first5 = L | authorlink5 = L Huybrechts | |||
| last6 = Lambrecht | first6 = L | authorlink6 = L Lambrecht | |||
| last7 = Paul | first7 = L | authorlink7 = L Paul | |||
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| title = Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study | |||
| journal = Journal of Internal Medicine | volume = | issue = | page = | |||
| date = September 2010 | |||
| pmid = 20412374 | |||
| doi = 10.1111/j.1365-2796.2010.02228.x | |||
}} | }} | ||
</ref> | </ref> |
Revision as of 14:56, August 16, 2016
Post-exertional malaise (PEM) is a worsening of many ME/CFS symptoms as a result of physical or mental exertion. It is often referred to as "the marker" by patients, ME/CFS organizatons, clinicians and researchers that work in the ME/CFS field. PEM can last for days to weeks after the exertion.[1][2]
2015 Institute of Medicine report[edit | edit source]
This landmark report published in 2015 by the United States Institute of Medicine report, which assessed all the evidence available, concluded:
"There is sufficient evidence that PEM is a primary feature that helps distinguish ME/CFS from other conditions"
Pages 84-86 of the report describe the evidence for post-exertional malaise in ME/CFS patients.[3]
Prevalence[edit | edit source]
Symptom recognition[edit | edit source]
Notable studies[edit | edit source]
- 1999, Demonstration of delayed recovery from fatiguing exercise in chronic fatigue syndrome
- 2013, Post-exertion malaise in chronic fatigue syndrome: symptoms and gene expression, Meyer et al, 2013[4]
- 2015, Myalgic Encephalomyelitis: Symptoms and Biomarkers, Jason et al, 2015[5]
- 2015, Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Shukla et al, 2015[6]
Notable articles[edit | edit source]
- Suggestion to replace PEM (Post Exertional Malaise) with PAR (Post Activity Relapse), ME Blogg, 2015[7]
Talks & interviews[edit | edit source]
- 2016, Inducing Post-Exertional Malaise in ME/CFS: A Look at the Research Evidence (Peter Rowe)
- 2015, Post-Exertion Malaise: The Intersection of Biology and Behavior, Dane Cook, Solve ME/CFS[8]
- 2015, 72. Gene-expression and exercise / Gen-expressie en inspanning – dr. Lucinda Bateman (Lucinda Bateman, Science for Patients)
- 2013, CFS gene expression after exercise (part 1) (Lucinda Bateman)
- 2012, Top 10 Things You Should Know About Post-Exertional Relapse (Staci Stevens)
Possible causes[edit | edit source]
Potential treatments[edit | edit source]
Learn more[edit | edit source]
- Post-Exertional Malaise in Chronic Fatigue Syndrome, Jennie Spotila, Solve ME/CFS, 2010[9]
- Post-Exertional Malaise: Cause and Effect, Jennie Spotila, Solve ME/CFS, 2012[10]
- Definition of Post-Exertional Malaise, About Health, 2015[11]
- Post-Exertional Malaise Video, ME/CFS Ghost, 2016[12]
- 2016, The Exercise Intolerance in POTS, ME/CFS and Fibromyalgia Explained?
See also[edit | edit source]
References[edit | edit source]
<references>
- ↑ 1.0 1.1 Johnson, C, Health Rising: ME/CFS Symptoms, retrieved Mar 2016 Check date values in:
|access-date=
(help) - ↑ 2.0 2.1 Fighting Fatigue, Post-Exertional Malaise – A Hallmark Symptom of ME/CFS, retrieved Mar 2016 Check date values in:
|access-date=
(help) - ↑ Institute of Medicine report pages 84-86, search term exercise
- ↑ 4.0 4.1 Meyer, JD; Light, AR; Shukla, SK; Clevidence, D; Yale, S; Stegner, AJ; Cook, DB (October 2, 2013), "Post-exertion malaise in chronic fatigue syndrome: symptoms and gene expression", Fatigue: Biomedicine, Health & Behavior, 1 (4): 190-209, doi:10.1080/21641846.2013.838444
- ↑ 5.0 5.1 Jason, LA; Zinn, ML; Zinn, MA (September 2015), "Myalgic Encephalomyelitis: Symptoms and Biomarkers", Current Neuropharmacology, 13(5): 701-734, doi:10.2174/1570159X13666150928105725
- ↑ 6.0 6.1 Shukla, SK; Cook, D; Meyer, JD; et al. (December 18, 2015), "Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)", Plos One, 10(12), doi:10.1371/journal.pone.0145453
- ↑ 7.0 7.1 ME Blogg (December 30, 2015), Suggestion to replace PEM by PAR
- ↑ 8.0 8.1 Cook, DB (November 19, 2015), "Deciphering Post Exertion Malaise: The Intersection of Biology and Behavior", Solve ME/CFS (video)
- ↑ 9.0 9.1 Spotila, JM (2010), "Post-Exertional Malaise in Chronic Fatigue Syndrome" (PDF), Solve ME/CFS
- ↑ 10.0 10.1 Spotila, JM (May 23, 2012), "Post-Exertional Malaise: Cause and Effect", Solve ME/CFS
- ↑ 11.0 11.1 About Health (October 8, 2015), Definition of Post-Exertional Malaise
- ↑ Post-Exertional Malaise - The ME/CFS Ghost
- ↑
Nijs, J; Van Oosterwijck, J; Meeus, M; Lambrecht, L; Metzger, K; Frémont, K; Paul, L (April 2010), "Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta", Journal of Internal Medicine, doi:10.1111/j.1365-2796.2009.02178.x, PMID 20433584 Invalid
|display-authors=7
(help) - ↑
Van Oosterwijck, J; Nijs, J; Meeus, M; Lefever, I; Huybrechts, L; Lambrecht, L; Paul, L (September 2010), "Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study", Journal of Internal Medicine, doi:10.1111/j.1365-2796.2010.02228.x, PMID 20412374 Invalid
|display-authors=7
(help)