Post-exertional malaise: Difference between revisions

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history
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| pmid    = 20433584
| pmid    = 20433584
| doi    = 10.1111/j.1365-2796.2009.02178.x
| doi    = 10.1111/j.1365-2796.2009.02178.x
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<ref name="VanOosterwijck2010">
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| last1  = Van Oosterwijck                  | first1 = J                  | authorlink1 = J Van Oosterwijck
| last2  = Nijs                  | first2 = J                  | authorlink2 = J Nijs
| last3  = Meeus                | first3 = M                  | authorlink3 = M Meeus
| last4  = Lefever                  | first4 = I                  | authorlink4 = I Lefever
| last5  = Huybrechts                  | first5 = L                  | authorlink5 = L Huybrechts
| last6  = Lambrecht                  | first6 = L                  | authorlink6 = L Lambrecht
| last7  = Paul                  | first7 = L                  | authorlink7 = L Paul
| display-authors = 7
| title  = Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study
| journal = Journal of Internal Medicine    | volume =    | issue =    | page =
| date    = September 2010
| pmid    = 20412374
| doi    = 10.1111/j.1365-2796.2010.02228.x
}}
}}
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Revision as of 14:56, August 16, 2016

Post-exertional malaise (PEM) is a worsening of many ME/CFS symptoms as a result of physical or mental exertion. It is often referred to as "the marker" by patients, ME/CFS organizatons, clinicians and researchers that work in the ME/CFS field. PEM can last for days to weeks after the exertion.[1][2]

2015 Institute of Medicine report[edit | edit source]

PEM chart from the 2015 Institute of Medicine report

This landmark report published in 2015 by the United States Institute of Medicine report, which assessed all the evidence available, concluded:

"There is sufficient evidence that PEM is a primary feature that helps distinguish ME/CFS from other conditions"

Pages 84-86 of the report describe the evidence for post-exertional malaise in ME/CFS patients.[3]

Prevalence[edit | edit source]

Symptom recognition[edit | edit source]

Notable studies[edit | edit source]

Post-exertional worsening of symptoms, VanNess et al 2010.png

Notable articles[edit | edit source]

Talks & interviews[edit | edit source]

Possible causes[edit | edit source]

Potential treatments[edit | edit source]

Learn more[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

<references>

[11]

[8]

[2]

[5]

[1]

[7]

[4]

[6]

[9]

[10]

[13]

[14]

  1. 1.0 1.1 Johnson, C, Health Rising: ME/CFS Symptoms, retrieved Mar 2016 Check date values in: |access-date= (help)
  2. 2.0 2.1 Fighting Fatigue, Post-Exertional Malaise – A Hallmark Symptom of ME/CFS, retrieved Mar 2016 Check date values in: |access-date= (help)
  3. Institute of Medicine report pages 84-86, search term exercise
  4. 4.0 4.1 Meyer, JD; Light, AR; Shukla, SK; Clevidence, D; Yale, S; Stegner, AJ; Cook, DB (October 2, 2013), "Post-exertion malaise in chronic fatigue syndrome: symptoms and gene expression", Fatigue: Biomedicine, Health & Behavior, 1 (4): 190-209, doi:10.1080/21641846.2013.838444
  5. 5.0 5.1 Jason, LA; Zinn, ML; Zinn, MA (September 2015), "Myalgic Encephalomyelitis: Symptoms and Biomarkers", Current Neuropharmacology, 13(5): 701-734, doi:10.2174/1570159X13666150928105725
  6. 6.0 6.1 Shukla, SK; Cook, D; Meyer, JD; et al. (December 18, 2015), "Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)", Plos One, 10(12), doi:10.1371/journal.pone.0145453
  7. 7.0 7.1 ME Blogg (December 30, 2015), Suggestion to replace PEM by PAR
  8. 8.0 8.1 Cook, DB (November 19, 2015), "Deciphering Post Exertion Malaise: The Intersection of Biology and Behavior", Solve ME/CFS (video)
  9. 9.0 9.1 Spotila, JM (2010), "Post-Exertional Malaise in Chronic Fatigue Syndrome" (PDF), Solve ME/CFS
  10. 10.0 10.1 Spotila, JM (May 23, 2012), "Post-Exertional Malaise: Cause and Effect", Solve ME/CFS
  11. 11.0 11.1 About Health (October 8, 2015), Definition of Post-Exertional Malaise
  12. Post-Exertional Malaise - The ME/CFS Ghost
  13. Nijs, J; Van Oosterwijck, J; Meeus, M; Lambrecht, L; Metzger, K; Frémont, K; Paul, L (April 2010), "Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta", Journal of Internal Medicine, doi:10.1111/j.1365-2796.2009.02178.x, PMID 20433584 Invalid |display-authors=7 (help)
  14. Van Oosterwijck, J; Nijs, J; Meeus, M; Lefever, I; Huybrechts, L; Lambrecht, L; Paul, L (September 2010), "Pain inhibition and postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: an experimental study", Journal of Internal Medicine, doi:10.1111/j.1365-2796.2010.02228.x, PMID 20412374 Invalid |display-authors=7 (help)