Portal:Energy metabolism
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Energy metabolism
Abnormalities in energy metabolism and exercise intolerance are key features of myalgic encephalomyelitis, whose cardinal symptom is post-exertional malaise. (more...)
Pyruvate dehydrogenase (PDH) is an enzyme that is part of the citric acid cycle. It catalyzes the reaction that transforms pyruvate into acetyl-CoA, a process called pyruvate decarboxylation. A large study by Fluge and Mella of 200 patients meeting the Canadian Consensus Criteria and 102 controls found a pattern of amino acids that suggested functional impairment of pyruvate dehydrogenase (PDH), supported by increased mRNA expression of the inhibitory PDH kinases 1, 2, and 4; sirtuin 4; and PPARδ in peripheral blood mononuclear cells from both sexes. (more...)
Dr J. Mark VanNess, PhD, is a member of the scientific advisory committee of the Workwell Foundation which specializes in two-day cardiopulmonary exercise test (2-day CPET) for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), fibromyalgia and other fatiguing conditions. He has been working on ME/CFS since 1999, and is particularly interested in issues of autonomic dysfunction and mechanisms that produce post-exertional malaise.
Dr VanNess serves as an Associate Professor of Health, Exercise & Sport Sciences, Department of Sport Sciences, and an Adjunct Instructor at the College of Engineering, both at the University of the Pacific, Stockton, California. (more...)
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Topics
- ATP-Dependent RNA Helicase DDX51
- Cell danger response hypothesis
- Cellular respiration
- Glycolysis
- Ketosis
- Kynurenine
- Kynurenine pathway
- Lactic acid
- Lactic acidosis
- Metabolic
- Metabolic features of chronic fatigue syndrome
- Metabolomics
- Methyl-CpG binding protein 2
- Mitochondrial disorder
- Nitrogen hypothesis
- Peroxisome
- Pyrroloquinoline Quinone
- VO2 Max
- Category:Anaerobic respiration
- Category:Beta-oxidation
- Category:Cellular respiration
- Category:Energy production or transportation symptoms
- Category:Metabolic diseases and disorders
- Category:Metabolic pathways
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