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Pleconaril
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'''Pleconaril (Picovir)''' is an [[antiviral]] drug developed by Schering-Plough, now Merck. It has activity against [[Picornaviridae]] viruses including [[Enterovirus]]es and [[Rinovirus]]es. Pleconaril has shown promise for the treatment of enteroviruses in a number of ''in vitro'' and clinical studies.<ref name="pleconarilrotbart2001" /><ref name="pleconarilpevear1999" /><ref name="pleconarilnewborns2002" /><ref name="pleconarilresistant1995" /><ref name="pleconarilinfants2003" /> The drug was available under [[compassionate use]] until 2003 and has not been approved by the [[FDA]]. ==Learn more== * "[https://www.medscape.com/viewarticle/410073_5 Pleconaril Treatment of Enterovirus and Rhinovirus Infections]," Infections in Medicine/Medscape, 2000 ==References== <references> <ref name="pleconarilrotbart2001">{{Citation| doi = 10.1086/318452| issn = 1058-4838| volume = 32 | issue = 2| pages = 228–235| last1 = Rotbart | first1 = Harley A. | last2 = Webster | first2 = A. David| title = Treatment of Potentially Life-Threatening Enterovirus Infections with Pleconaril| journal = Clinical Infectious Diseases| access-date = 2016-11-09| date = 2001-01-15| url = http://cid.oxfordjournals.org/content/32/2/228 | pmid = 11170912}}</ref> <ref name="pleconarilpevear1999">{{Citation| issn = 0066-4804| volume = 43 | issue = 9| pages = 2109–2115| last1 = Pevear | first1 = Daniel C. | last2 = Tull | first2 = Tina M. | last3 = Seipel | first3 = Martin E. | last4 = Groarke | first4 = James M.| title = Activity of Pleconaril against Enteroviruses| journal = Antimicrobial Agents and Chemotherapy| access-date = 2016-11-09| date = 1999-09-01| url = http://aac.asm.org/content/43/9/2109 | pmid = 10471549}}</ref> <ref name="pleconarilnewborns2002">{{Citation| doi = 10.1007/s00431-002-0929-5| issn = 0340-6199| volume = 161 | issue = 9| pages = 491–493| last1 = Bauer | first1 = Sofia | last2 = Gottesman | first2 = Giora | last3 = Sirota | first3 = Lea | last4 = Litmanovitz | first4 = Ita | last5 = Ashkenazi | first5 = Shay | last6 = Levi | first6 = Itzhak| title = Severe Coxsackie virus B infection in preterm newborns treated with pleconaril| journal = European Journal of Pediatrics| access-date = 2016-11-09| date = 2002-09-01| url = http://link.springer.com/article/10.1007/s00431-002-0929-5}}</ref> <ref name="pleconarilresistant1995">{{Citation| doi = 10.1086/314758| issn = 0022-1899| volume = 179 | issue = 6| pages = 1538–1541| last1 = Groarke | first1 = James M. | last2 = Pevear | first2 = Daniel C.| title = Attenuated Virulence of Pleconaril-Resistant Coxsackievirus B3 Variants| journal = Journal of Infectious Diseases| access-date = 2016-11-09| date = 1999-06-01| url = http://jid.oxfordjournals.org/content/179/6/1538 | pmid = 10228078}}</ref> <ref name="pleconarilinfants2003">{{Citation| doi = 10.1097/01.inf.0000059765.92623.70| issn = 0891-3668| volume = 22 | issue = 4| pages = 335–341| last1 = Abzug | first1 = Mark J. | last2 = Cloud | first2 = Gretchen | last3 = Bradley | first3 = John | last4 = Sánchez | first4 = Pablo J. | last5 = Romero | first5 = José| last6 = Powell | first6 = Dwight | last7 = Lepow | first7 = Martha | last8 = Mani | first8 = Chitra | last9 = Capparelli | first9 = Edmund V. | last10 = Blount | first10 = Sharon | last11 = Lakeman | first11 = Fred | last12 = Whitley | first12 = Richard J. | last13 = Kimberlin | first13 = David W. | last14 = National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group| title = Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis| journal = The Pediatric Infectious Disease Journal| date = April 2003 | pmid = 12690273}}</ref> </references> [[Category:Potential treatments]] [[Category:Antivirals]]
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