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Pesticide exposure link to ME/CFS
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==== Organophosphates cause immunosuppression ==== A study in sheep found that the organophosphateĀ pesticide parathion suppressed both the IgM and IgG immune antibodyĀ responses, which is thought to be due to the Ā cholinergicĀ stimulationĀ caused by organophosphates.<ref>{{Cite journal | last = Casale | first = G. P. | last2 = Cohen | first2 = S. D. | last3 = DiCapua | first3 = R.A. | date = Apr 1983 | title = The effects of organophosphate-induced cholinergic stimulation on the antibody response to sheep erythrocytes in inbred mice|url=https://www.ncbi.nlm.nih.gov/pubmed/6857660|journal=Toxicology and Applied Pharmacology|volume=68|issue=2|pages=198ā205|doi=10.1016/0041-008x(83)90004-2|issn=0041-008X|pmid=6857660|pmc=|quote=|access-date=|via=}}</ref>Ā This may in part explain why organophosphate exposure is a risk factor for ME/CFS, as this disease is usually precipitated by a viral infection, and immunosuppression during the acute phase of infection may allow the virus to breach into tissues compartments such as the brain which it would normally not reach. Exposure to immunosuppressiveĀ corticosteroidsĀ during acute viral infection is also a risk factor for developing ME/CFSĀ from the infection (see [[corticosteroids given during acute viral infection may trigger myalgic encephalomyelitis]]).
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